TCA's chemical strategy

Question 1

TCA supplies reactants for biosynthesis, which means?

Answer 1

TCA is amphibolic,is catabolic and anabolic

Question 2

CoA

Answer 2

carries acetyl groups.
Has two carbons, must form a thioester
gives a high energy compound…

Question 3

Three groups of high energy compounds

Answer 3

1. phosphoanhydride/ phosphoesters
2. B-keto acid
3. Thioesters

Question 4

Acetyl group of CoA

Answer 4

• oxidized by teh TCA to 2 CO2 molecules, which requires transfer of 4 pairs of electrons.

3 pairs : 3 NAD+ to 3 NADH
1 pair: FAd to FADH2

Question 5

Why need a feed rxn?

Answer 5

because acetyl CoA is not pyruvate, need to decarboxylate acetyl group to add to coA…
Feeder rxn is PDHC.
- occurs in mito
- CO2’s are lost from an acetyl coa added in A PRIOR turn.