PDHC rxn outline

Question 1

Mammals have many lipolysine/lipoamide arms per PDHC complex

Answer 1

1 E1 can acetylate numerous E2 lipolysyl arms….
1 E3 can reoxidize several dihydrolipoamides.

This reinforces why the stoichiometry of E1, E2 and E3 is not 1:1:1…