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Biochemistry > TCA > Flashcards

TCA Flashcards

1
Q

NAD+ is derived from?

A

Vitamin Niacin (3)

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2
Q

FAD is derived from?

A

Vitamin Riboflavin (2)

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3
Q

Coenzyme A (CoA) is the condensation product of ___, ___, and ___.

A

Cysteine, B5 (Pantothenic acid), and ATP

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4
Q

Acetyl group is bond to Mercaptoethylamine residue via what bond?

A

Thioester (High energy)

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5
Q

Mercaptoethylamine residue is bond to Pantothenic acid residue through what bond?

A

Amide bond

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6
Q

ATP is bond to Pantothenic acid residue via what bond?

A

Phosphester

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7
Q

What is the oxidizing agent for pyruvate dehydrogenase complex?

A

NAD+

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8
Q

Pyruvate dehydrogenase deficiency is the most common biochemical cause of congeital_____.

A

lactic acidosis.

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9
Q

Thiamine pyrophosphate (TPP) is bound to ___ which decarboxylates pyruvate.

A

E1

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10
Q

Lipoic acid is bound to___ which accepts the hydroxyethyl carbanion.

A

E2

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11
Q

Coenzyme A (CoA) is a substrate for ___ which accepts the acetyle group.

A

E2

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12
Q

Flavin adenine dinucleotide (FAD) is bound to___ which is reduced by lipoamide.

A

E3

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13
Q

Nicotinamide adenine dinucleotide (NAD+) is a substrate for___ which is reduced by FADH2.

A

E3

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14
Q

Arsenic compounds are poisonous because they sequester____?

A

Lipoic acid.

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15
Q

What is the first irreversible (RL) step?

A

Citrate synthase

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16
Q

Second irreversible step (RL) is?

A

Isocitrate dehydrogenase

17
Q

GTP is synthesized via _____ phosphorylation.

A

Substrate-level

18
Q

GTP can donate phophoryl group to ADP to form ATP, reversible, by which enzyme?

A

Nucleoside diphosphate kinase

19
Q

Which enzyme of the TCA cycle is embedded in the inner mitochondrial membrane?

A

Succinate dehydrogenase

20
Q

Where all all, beside one, enzymes located?

A

Mitochondrial MATRIX

21
Q

What is the oxidizing agent for TCA enzymes?

A

NAD+

22
Q

What is the product of TCA cycle?

A

3 NADH, 1FADH2, 1 GTP

23
Q

How many ATPs are produced via 1 Acetyl CoA?

A

12

24
Q

How many pairs of electrons are transferred during one turn?

A

4

25
Q

TCA cycle has a ____ nature.

A

Amphibolic (Catabolic and anabolic pathway)

26
Q

What pathways utilize TCA intermediates (Succinyl CoA mostly)?

A

Gluconeogenesis, GA and cholesterol synthesis, AA biosynthesis, and Porphyrin biosynthesis.

27
Q

Does pyruvate carboxylase replenish TCA?

A

Yes!

28
Q

What are the 3 anaplerotic degradative pathways?

A

Oxidation of odd-chain FA, Catabolism of AA isoleucine, methionine and valine. Transamination and deamination of AA.

Biochemistry (10 decks)

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