Eicosanoids

Question 1

DihomoGLA makes what? This is which series of prostaglandins?

Answer 1

PGE1, Series-1 prostaglandins

Question 2

Arachidonic acid makes what? This is which series of prostaglandins?

Answer 2

PGE2, Series-2 prostaglandins

Question 3

Eicosapentaenoic acid makes what? This is which series of prostaglandins?

Answer 3

PGE3, Series-3 prostaglandins

Question 4

PGE3 is how many times less inflammatory as PGE1?

Answer 4

100 times

Question 5

Arachidonic acid will form Leukotriene E4 (LTE4) via which enzyme?

Answer 5

5-Lipoxygenase

Question 6

What prevents the production of LTE4 by inhibiting the enzyme 5-Lipoxygenase?

Answer 6

Zileuton (Asthma drug)

Question 7

What is Cyclooxygenase Isoenzyme?

Answer 7

It’s different COX enzymes that do the same job

Question 8

What are the two COX isoenzymes?

Answer 8

COX 1 and 2

Question 9

Which COX enzyme is a constitutive of gastric mucosa, platelets, vascular endothelium and kidney (PRODUCES “HOUSEKEEPING” PROSTAGLANDINS)?

Answer 9

COX-1

Question 10

Which COX enzyme is inducible and is produced in response to inflammation (PRODUCES INFLAMMATORY PROSTAGLANDINS)?

Answer 10

COX-2

Question 11

What is the RL step in the production of Arachidonic acid?

Answer 11

Phospholipase A2

Question 12

Everything in the body makes eicosanoids besides?

Answer 12

RBCs

Question 13

Vasodilation, potentiate edema, induces fever, causes pain. These are the actions of which eicosanoid?

Answer 13

Prostaglandins (PGE2); Very widely distributed

Question 14

Vasodilation and inhibits platelet agreegation. These are the actions of which eicosanoid? Where are they synthesized?

Answer 14

Prostacyclins (PGI2); vascular endothelium

Question 15

Vasoconstriction, promotes platelet aggregation. These are the actions of which eicosanoid? Where are they synthesized?

Answer 15

Thromboxanes (TXA2); Platelets

Question 16

Vasoconstriction, bronchoconstriction, increased vascular permeability, increased PMN’s chemotaxis. These are the actions of which eicosanoid? Where are they synthesized?

Answer 16

Leukotrienes; Leukocytes

Question 17

What inhibits both COX-1 and 2?

Answer 17

Asprin

Question 18

Does acetaminophen bind to COX-1 or 2? What does it inhibit?

Answer 18

No it does not. Inhibits COX-3

Question 19

Why does Greenland Eskimos have very low incident of heart disease dispite high dietary intake of cholesterol and fat?

Answer 19

Consumption of marine animal provides them with a high proportion of omega-3 fats.