TB Vaccines Flashcards by emily chetwin | Brainscape

Q

How can macrophages kill M.tuberculosis?

A

pathogen recognition (TLRs)
phagosome maturation
antimicrobial factos (cathelicidin)
inflammatory response

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

How does TB fight back against macs?

A

prevents phagosome maturation

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

2 NB innate factors for killing TB

A

IFN-y

TNF-a

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Why does BCG not work?

A

passage of bacteria may have resulted in loss of virulence
different strains of BCG may have different efficacy
exposure to environmental mycobac may mask response to BCG
infections with other pathogens may interfere with response to BCG

How well did you know this?

1

Not at all

2

3

4

5

Perfectly