TB Flashcards
what is the epidemiology of TB
the disease burden from TB globally is falling
NO1 killer that’s is a communicale disease
where is TB a problem in the UK
in highly built areas such as London
high immigrant population
how does TB spread
its a airborne
TB in lungs sneezes, yells sings
what is the clinical presentation of TB
cough - mainly
fever
night sweats
weight loss
the bottom 3 can be absent in up to 1/3 of presentations
what causes TB
mycobacterium
what are some of the mycobacteria
M.tuberculosis
M.africanum
M.bovis
what is the take home message for mycobacteria in TB
not all AAFBs are TB
what are the 3 outcomes of the TB primary infection
progressive disease
contained - latent
cleared/cured
what is the immunopathology of Tb
activates macrophages, leads to accumulation of macrophages, causing granulomas
what is the diagnosis of TB
chest X-ray
bronchoscopy
what is important in the treatment of TB
identify the bug
using a bronchoscopy
induced sputum sample
what is the treatment regime (time and drugs) for TB
4 drugs for 2 months
2 drugs for 4 months
what are the 4 drugs taken for TB
isoniazid
pyrazinamide
rifampicin
ethambutol
what are the 2 drugs taken for 4 months
rifampicin
isoniazid
what are some side effects of TB drugs
orange (irn bur) teats, urine
hepatitis - the drugs are very damaging to the liver
