TB

Question 1

Rifampacin mechanism

Answer 1

Inhibit bacterial DNA dependent RNA polymerase preventing transciption of DNA to mRNA

Question 2

Isoniazid mechansim

Answer 2

Inhibit mycolic acid synthesis

Question 3

Pyrazinamide mechanism

Answer 3

Convert pyrazinamidase iinto pyrazinoic acid which inhibits fatty acid synthase I

Question 4

Ethambutol mechanism

Answer 4

Inhibits arabinosyl tarnsferase which polymerises arabinose into arabinan

Question 5

Rifampacin side effects

Answer 5

Orange secretions
Hepattis
Flu like symptoms
P450 inducer

Question 6

Isoniazid side effects

Answer 6

Peripheral myopathy
Hepatitis
Agranulocytosis
P450 inhibitor

Question 7

Pyrazinamide side effects

Answer 7

Hyperuricaemia –> gout
Arthralgia, myalgia
Hepatitis

Question 8

Ethambutol side effects

Answer 8

Optic neuritis

Question 9

TB treatment protocol - active

Answer 9

2 months RIPE then 4 months RI

Question 10

TB treatment protocol - latent

Answer 10

3 months RI or 6 months isoniazid

Question 11

TB treatment protocol - meningeal

Answer 11

Minimum 12 months treatment
Steroids

Question 12

What is important with isoniazid?

Answer 12

Prevent peripheral neuropathy with pyridoxine (vit B6)