Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Drugs MRCP > Chemotherapy > Flashcards

Chemotherapy Flashcards

1
Q

What is the mechanism of action of cyclophosphamide?

A

Alkylating agent
Causes cross linking in DNA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are the adverse effects of cyclophosphamide?

A

Haemorrhagic cystitis
Myelosuppression
Transitional cell carcinoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is the mechanism of action of Bleomycin?

A

Degrades preformed DNAat

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

is the big adverse effect of bleomycin?

A

Lung fibrosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What are some examples of anthracyclines?

A

Doxorubicin
Daunorubicin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is the mechanism of action of anthracyclines?

A

Inhibits DNA and RNA synthesis by stabilising DNA topimerase II complex

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Whatt is the big adverse effect of anthracyclines?

A

Cardiomyopathy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What are some antimetabolite cytotoxics? x4

A

Methotrexate
5FU
Mercaptopurine
Cytarabine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is the mechanism of action of methotrexate?

A

Inhibits dihydrofolate reductase and thymidylate synthesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What are the main adverse effects of methotrexate?

A

Mucositis
Liver fibrosis
Lung fibrosis
Myelosuppression

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is the mechanism of action of 5FU?

A

Pyrimidine analogue
Induces cell cycle arrest and apoptosis by blocking thymidylate synthase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What are the adverse effects of 5FU?

A

Mucositis and diarrhoea
Myelosuppression
Dermatitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is the mechanism of action of mercaptopurine?

A

Purine analogue
Decreases purine synthesis
Activated by HGPRTase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is the adverse effect of mercaptopurine?

A

Myelosuppression

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is the mechanism of action of cytarabine?

A

Pyrimidine antagonist
Interferes with DNA synthesis and inhibits DNA polymerase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What are some microtubule inhibitors?

A

Vincristine/vinblastine
Docetaxel

17
Q

What is the mechanism of action of vincristine?

A

Inhibits formation of microtubules

18
Q

What are the adverse effects of vincristine?

A

Peripheral neuropathy - reversible
Paralytic ileus

19
Q

What is the mechanism of action of docetaxel?

A

Prevents microtubule depolymerisation and disassembly, decreasing free tubulin

20
Q

What is the main adverse effect of docetaxel?

A

Neutropenia

21
Q

What is the mechanism of action of irinotecan?

A

Inhibits topimerase I which prevents relaxation of supercoiled DNA

22
Q

What is the adverse effect of irinotecan?

A

Myelosuppression

23
Q

What is the mechanism of action of cisplatin?

A

Causes cross linking in DNA

24
Q

What are the adverse effects of cisplatin?

A

Ototoxicity
Peripheral neuropathy
Renal toxicity
Low magnesium

25
Q

What is the mechanism of action of hydroxycarbamide?

A

Inhibits ribonucleotide reductase, decreasing DNA synthesis

26
Q

What is the adverse effect of hydroxycarbamide?

A

Myelosuppression

27
Q

What is given alongside cyclophosphamide and why?

A

Mesna
Binds to acrolein, metabolite produced which is toxic to urothelium

28
Q
A

Drugs MRCP (7 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions