Chemo mechanisms Flashcards
1
Q
cyclophosphamide
A
cross linking of DNA
2
Q
cisplatin
A
cross linking of DNA
3
Q
5FU
A
Induce cell cycle arrest and apoptosis via thymidylate synthase
4
Q
cytarabine
A
Inhibit DNA polymerase and DNA synthesis
5
Q
Methotrexate
A
Inhibit dihydrofolate reductase and thymidylate synthase
6
Q
Mercaptopurine
A
Decrease purine synthesis
7
Q
Vincristine
A
Inhibit microtubule formation
8
Q
Docetaxel
A
Prevent microtubule depolymerisation and disassembly, decerasing free tubulin
9
Q
Irinotecan
A
Inhibit topimerase I to prevent relaxation of supercoiled DNA
10
Q
Bleomycin
A
Degrades preformed DNA
11
Q
Doxorubicin
A
stabilises DNA topimerase II complex to decrease DNA and RNA synthesis
12
Q
Hydroxycarbamide
A
Inhibit ribonucleotide reductase, decreasing DNA synthesis
