Antibiotic mechanisms and resistance

Question 1

Inhibit cell wall synthesis

Answer 1

Cell Can’t Produce Vall
Cephalosporins
Carbopenems
Penicillins
Vancomycin

Question 2

Inhibit protein synthesis - 50S

Answer 2

Cell Can’t Synthesise Like Meat
Chloramphenicol
Clindamycin
Streptogrammins
Linezolid
Macrolides

Question 3

Inhibit protein synthesis - 30S

Answer 3

AT all
Aminoglycosides
Tetracycles

Question 4

Inhibit DNA Synthesis

Answer 4

Quinolones

Question 5

Damage DNA

Answer 5

Metro

Question 6

Inhibit folic acid synthesis

Answer 6

Trimethoprim
Sulfonamides

Question 7

Mechanism of resistance - macrolides

Answer 7

Post transcription methylation of 23S bacterial ribosomal RNA

Question 8

Mechanism of resistance - quinolones

Answer 8

Mutation to DNA gyrase efflux pumps, causing decreased intracellular concentration of quinolones

Question 9

Mechanism of resistance - cephalosporins

Answer 9

Changes to penicillin binding proteins

Question 10

Mechanism of resistance - vancomycin

Answer 10

Alteration of terminal amino acid residues of NAM/NAG peptide subunits to which antibiotic binds

Question 11

Bactericidal antibiotics

Answer 11

PANIC RM Q
Penicillins
Aminoglycosides
Nitro
Isoniazid
Cephalosporins
Rifampacin
Metro
Quinolones

Question 12

Bacteriostatic

Answer 12

STaT MC
Sulphonamides
Trimethoprim
Tetracycles
Macrolides
Chloramphenicol