Targeted Cancer Therapy Drugs

Question 1

Alkylating Agents

Answer 1

Interfere with DNA replication in a manner similar to radiation therapy. Most are cell cycle non-specific

Question 2

Busulfan (Myleran)

Answer 2

Specific Side Effect: Pulmonary fibrosis

Question 3

Cisplatin (Platinol)

Answer 3

Specific Side Effect: Renal Toxicity

Question 4

cyclosphospamide (Cytoxan) DEF TEST ?

Answer 4

Specific Side Effect: Hemorrhagic cystitis; capillary leak syndrome. NOTE: VIP to drink to purge from system do not take at night.

Question 5

ifosfamide (Ifex)

Answer 5

Specific Side Effect: metabolic encephalopathy

Question 6

Nitrosureas

Answer 6

Similar to Alkylating agents

Question 7

Carmustine (BCNU)

Answer 7

Specific Side Effect: Delayed myelosuppression; pulmonary Fibrosis

Question 8

Anti Metabolites

Answer 8

Inhibit enzymes involved in nucleic acid synthesis. Because they are chemically similar to Metabolites, the agents are incorporated into the cell structure and block further cellular activities

Question 9

Cytarabine (ARA-C)

Answer 9

Specific Side Effect: Hepatotoxicity, capillary leak syndrome; metabolic encephalopathy

Question 10

methotrexate (Folex)

Answer 10

Specific Side Effect: hepatotoxity, metabolic encephalopathy, renal toxicity

Question 11

hydroxyurea (Hydrea)

Answer 11

Specific Side Effect: hallucinatiions, hepatic/renal disorders

Question 12

Antitumor antibiotics

Answer 12

Directly bind with DNA to prevent further DNA and RNA synthesis. Severely Toxic to Tissue. Vesicants (Very Destructive) Indications for Use: Hodgkin’s Lymphoma, Non-Hodgkin’s lymphoma, Leukemia, many cancers

Question 13

daunorubicin (DaunoXome)

Answer 13

Specific Side Effect: Myocardial Toxicity

Question 14

doxorubicin (Adriamycin)

Answer 14

Specific Side Effect: Myocardial Toxicity secondary prevention (dexrazoxane (Zineard))

Question 15

Bleomycin (Blenoxane)

Answer 15

Specific Side Effect: pulmonary Toxicity, Renal hepatic Toxicity

Question 16

Mitotic Spindle poisons

Answer 16

These are plant extracts that arrest cell division, used wit Hodgkins lymphoma, lymphoma, and cancers. (also know as Plant Alkaloids)

Question 17

vincristine (Oncovin)

Answer 17

Specific Side Effect: Impotence, bone pain, neurotoxic

Question 18

vinblastine (Velban)

Answer 18

Specific Side Effect: Constipation, loss of reflexes, neurotoxic, paryletic illius

Question 19

What are the Common toxic effects of almost all chemotherapy drugs.

Answer 19

Bone Marrow suppression, nausea, vomiting, diarrhea, stomatitis, alopecia

Question 20

Ibritumonab (Zevalin)

Answer 20

targets the CD20 Antigen to DELIVER RADIATION. used for certain Non- Hodgkin Lymphoma.

Question 21

What is needed when handling, preparing, and administering radiopharmaceuticals

Answer 21

Appropriate protective precautions.

Question 22

Test Question: Typical Adverse reactions to targeted cancer therapies differ from those of traditional anti-neoplastics. Name some examples

Answer 22

Nausea, Vomiting, Aloecia are not commonly caused.