Targeted Cancer Chemotherapy - Pharmacology

Question 1

Dasatinib - Mechanism + Key Use + Toxicity

Answer 1

Mechanism - Tyrosine Kinase inhibitor - Bcr-Abl + c-kit + PDGFR
Key Use - CML + ALL - Avoids resistance found in most imatinibi
Toxicity - Pulmonary Edema + Fluid Retention

Question 2

Nilotonib - Mechanism + Key Use + Toxicity

Answer 2

Mechanism - Tyrosine Kinase inhibitor - Bcr-Abl + c-kit + PDGFR
Key Use - CML + ALL - Avoids resistance found in most imatinibi
Toxicity - Pulmonary Edema + Fluid Retention

Question 3

Lapatinib - Mechanism + Key Use

Answer 3

Mechanism - HER1/2 Competitive Inhibitor

Key Use - Combination HER2 Breast Cancer Therapy

Question 4

Sorafenib - Mechanism + Key Use + Toxicity (2)

Answer 4

Mechanism - VEGF Inhibitor (Inhibits Angiogenesis)
Key Use - Advanced Renal Cell Cancer
Toxicity - HTN + Hand and Foot Syndrome

Question 5

Sunitinib - Mechanism + Key Use

Answer 5

Mechanism - VEGF Inhibitor (Inhibits Angiogenesis)

Key Use - Advanced Renal Cell Cancer

Question 6

Cetuximab - Mechanism + Key Use + Toxicity

Answer 6

Mechanism - EGFR Receptor Inhibitor (Extracellular Domain)
Key Use - KRAS Negative Metastatic Colon Cancer
Toxicity - Can’t be used with KRAS+ Colon Cancer

Question 8

Pantiumumab - Mechanism + Key Use + Toxicity

Answer 8

Mechanism - EGFR Receptor Inhibitor
Key Use - KRAS Negative Metastatic Colon Cancer
Toxicity - Can’t be used with KRAS+ Colon Cancer - Also causes aceiform skin rash + hypomagnesemia

Question 8

Pertuzumab - Mechanism + Key Use

Answer 8

Mechanism - HER1/2 Competitive Inhibitor

Key Use - Combination HER2 Breast Cancer Therapy

Question 9

Bortezomib - Mechanism + Key Use + Toxicity

Answer 9

Velcade

Mechanism - Proteosome Inhibitor
Key Use - Multiple Myeloma
Toxicity - Peripheral Neuropathy

Question 10

L-Asparaginase - Mechanism + Key Use + Toxicity (3)

Answer 10

Mechanism - Deplete L-Asparagine from the blood which cancer cells cannot produce on their own
Key Use - Childhood ALL
Toxicity - DIC + Pancreatitis + Neurotoxicity