Reproductive - Pharmacology - Class

Question 1

Mild Toxicities of Oral Contraceptives (4)

Answer 1

1) Nausea
2) Bleeding Edema (Estrogen)
3) Headache (Migraine)
4) Withdrawal Bleeding

Question 2

Moderate Toxicities of Oral Contraceptives (4)

Answer 2

1) Weight Gain
2) Acne
3) Hirsutism (in androgen containing formulations)
4) Ureteral Dilation (increasing vaginal infections)

Question 3

Severe Toxicities of Oral Contraceptives (5) + Impacting Factor

Answer 3

All Worse with Smoking

1) Venous Thromboembolism
2) MI
3) CVD
4) Cholestatic Jaudice
5) Depression

Question 4

Contraindications for Oral Contraceptives (5)

Answer 4

1) Smoking Age > 35
2) LIver Disease (Don’t Clear Hormone)
3) CYP3A4 Drugs (Valproic Acid)
4) HTN
5) Asthma

Question 5

Oral Contraceptive Drug Interactions (3)

Answer 5

1) Anti-microbials - Knock out GI Flora - Reduce Absorption + Increase Pregnancy Change
2) St. John’s Wort (CYP3A4)
3) Valproic Acid (CYP3A4)

Question 6

Clompihene - Mechanism + Use + Toxicities

Answer 6

Selective Estrogen Receptor Modulator - Inhibits Stronger Estrogen causing increases GnRH and E2 - Stimulates ovulation

Use - Stimulate Ovulation/Pregnancy (Pre-IVF)

Toxicity - Hot Flashes + Heavier Cycle + Multiple Pregnancies

Question 7

Leoprolide - Mechanism + Use

Answer 7

GnRH Agonist - Used for anovulotory women who don’t respond to clomiphen for IVF

Question 8

Gonorrhea - UTI Presentation

Answer 8

Gram Negative Coffee Bean Cocci
Pelvic Inflammatory Disease
Creamy Purulent Dischage
Tx = Ceftriaxone

Question 9

Chlamydia - UTI Presentation

Answer 9

Cytoplasmic Inclusions on Lab
With Gonorrhea
Pelvic Inflammatory Disease
Tx = Azirthromycin + Docecyclin

Question 10

Herpes - UTI Presentation

Answer 10

Herpevirus - DNA + Linear
Painful vesicles and ulcers with systemic signs/symptoms
Tx = Acyclovir

Question 11

Trichomonias - UTI Presentation

Answer 11

Anerobe - Motile on Wet Slide
Strawberry Cervix
Frothy Gray Foul Smelling Discharge
Tx. Metrozonidazole

Question 12

Ceftriaxone - UTI Use + Mechanism

Answer 12

Gonorrhea - B-Lactam Cell Wall Abx - Bacteriocidial

3rd Generation Cephalosporine

Question 13

Azithromycin - UTI Use + Mechanism

Answer 13

Chlaymida - 50S Subunit inhibitor - Bacteriostaric

Macrolide

Question 14

Doxycycline - UTI Use + Mechanism

Answer 14

Chlaymida - 30S Subunit Inhibitor
Bacteriostatic

Tetracycline

Question 15

Acyclovir - UTI Use + Mechanism + AE (4)

Answer 15

Herpes - Inhibits viral DNA synthesis

AEs - Nausea + Vomiting + Rash + Seizures

Question 16

Metronidazole - UTI Use + Mechanism + AE (1)

Answer 16

Trichamonas - Binds proteins leading to loss of function + DNA DS Breaks
Pyruvate Ferredoxin-Oxidoreducatase needed

AE = Orange Urine