Neurology - Pharmacology Flashcards
Parkinson’s Drugs (5) - Name/Class + Basic Mechanism
BALSA
1) Bromocriptine (Ergot Dopamine Agonist)
2) Amantadine (Increases Dopamine Release)
3) Levodopa/Carbidopa (Converted to Dopamine in the CNS)
4) Selegiline (Selective MAO Inhibitor - Decreases Dopamine Breakdown)
5) Benztorpine (Antimuscarinic)
Dopamine Agonists (3)
1) Bromocriptine (Ergot)
2) Pramipexole (Non-Ergot)
3) Ropinirole (Non-Ergot)
Non-Ergot = Less Side Effects
Dopamine Breakdown Inhibitors (3)
1) Selegiline (MAO Type B Inhibitor)
2) Entacapone (COMT Inhibitor - Prevent L-Dopa Breakdown - Increase Dopa. Availability)
3) Tolcapone (COMT Inhibitor - Prevent L-Dopa Breakdown - Increase Dopa. Availability)
Levodopa - Class + Mechanism + Use + Toxicity
L-Dopa - Alternative Form of Dopa - Saved for CNS - Crosses Blood Brain Barrier - Converted to Dopa in CNS
Use - Parkinson’s Disease (With Carbidopa to reduce the concentration needed)
Toxicity - Arrhythmias + Dyskinesia (On-Off Syndrome mixed with Akinesia)
Selegiline - Class + Mechanism + Use
Class - MAO-B Inhibitor - Prevents Dopa breakdown (vs. NE)
Use - Parkinson’s Disease (Along with L-Dopa)
Toxicity - May enhance L-Dopa toxicity
Entacapone + Tolcapone - Class + Use
Class - COMT Inhibitors
Parkinson’s Disease - Reduces Dopamine breakdown
Parmipexole + Ropinirole - Class + Use
Class - Non-Ergot Dopamine Agonists
Use - Parkinson’s Disease
Sumatriptan - Class + Mechanism - Use + Toxicity
Class - 5-HT Serotonin Agonist
Mechanism - Inhibits trigeminal nerve activation
Use - Migraine Headaches (Acute) + Cluster Headaches
Toxicity - Coronary Vasospasm (Don’t give to patients with CAD or Prinzmetal angina)
Tetrabenazine + Reserpine - Class + Use
Class - Inhibit vesicular monoamine transporter (Decrease GABA/Ach)
Use - Huntington’s Disease
Haloperidol - Class + Use
Class - Dopamine Receptor Antagonist
Use - Huntington’s Disease
