Adrenergics - Pharmacology

Question 0

Catecholamine Receptors (Alpha-Beta-Dopa)

Answer 0

B1/2/3 = Gs
A1 = Gq
A2 = Gi
D1 = Gs
D2 = Gi

Question 1

Clonidine - Class + Use + Toxicity

Answer 1

Class - Direct Non-Catecholamine
Use - A2 Selective > A1 with no Beta for Anti-HTN - Usually via transdermal patch
Toxicity - CNS Depression/Sedation + Rebound HTN is stopped suddenly

Question 2

Direct Non-Catecholamine Sympathomimetics - Names (4) + Mechanism

Answer 2

Phenylephrine - Alpha 1 Selective > A2 with no Beta
Clonidine - Alpha 2 Selective > 1 with no Beta
A-Methyldopa - Alpha 2 Selective > 1 with no Beta
Albuterol - Beta 2 Selective > 1 with no Alpha

Question 3

Epinephrine - Class + Use + Toxicity

Answer 3

Class - Catecholamine
Use - Non-Selective - Anaphlactic Shock + Acute Asthmatic + Prolonged Anesthesia + Open Angle Glaucoma
Toxicity - Marked Hypertension + Arrhythmia + Angina + Necrosis

Question 4

Phenylephrine - Class + Use + Toxicity

Answer 4

Class - Direct Non-Catecholamine
Use - A1 Selective > A2 with no Beta Neurogenic Shock + Nasal Decongestion
Toxicity - HTN + Stroke + MI

Question 5

Beta Adrenergic Blockers - Names (4) + Mechanisms (3)

Answer 5

Prototypical - Propranolol (olol) - Non-Selective
Atenolol + Metaprolol - B1 Selective (Cardiac)
Esomolol - Very Rapid + Short Half Life

Question 6

Direct Catecholamines - Names (5) + Mechanism

Answer 6

Epinephrine - Non-Selective (A1,A2,B1,B2)
Norepinephrine - Non-Selective (A1,A2,B1,B2)
Isoproterenol - Beta Selective (No Alpha)
Dopamine - D1 and D2
Dobutamine - B1 > B2 with no Alpha

Question 7

Propranolol - Class + Use + Toxicity

Answer 7

Class - Non-Selective Beta Blocker
Use - HTN - Arrhythmia + Tremor + Stage Fright + Local Anesthetic
Toxicity - Low Beta Symp. Activity - Bronchospasm + AV Block + Heart Failure

Question 8

Dobutamine - Class + Use

Answer 8

Class - Catecholamine

Use - B1 Selective > B2 with No Alpha - Inotropic effects - Used in CHF

Question 10

Isoproterenol - Class + Use

Answer 10

Class - Catecholamine

Use - Beta Selective - Acute Asthma - Decreases BP and Increases HR

Question 12

Dopamine - Class + Use + Toxicity

Answer 12

Class - Catecholamine
Use - D1 and D2 - Shock especially with renal failure
Toxicity - Cardiovascular + Arrhythmia

Question 13

A-Methyldopa - Class + Use + Toxicity

Answer 13

Class - Direct Non-Catecholamine
Use - A2 Selective > A1 with no Beta for Anti-HTN in pregnancy
Toxicity - Direct Coombs hemolytic anemia = SLE-Like Syndrome

Question 14

Norepinephrine - Class + Use + Toxicity

Answer 14

Class - Catecholamine
Use - Non-Selective - Shock (Especially Septic)
Toxicity - Vasosparm + Skin Necrosis + MI + Arrhythmia + HTN

Question 14

Indirect Non-Catecholamine Sympathomimetics - Names (3) + Mechanism)

Answer 14

Amphetamine + Methamphetamine

Mechanism - Increased Catecholamine Release

Question 15

Doxazosin - Class + Use + Toxicity

Answer 15

Class - A1 Selective Alpha Blocker
Use - HTN - Reduce Preload + Afterload via vasodilation without hypotension + BPH
Toxicity - Orthostatic HTN (with first dose) and no tachycardia

Question 16

Albuterol - Class + Use + Toxicity

Answer 16

Class - Direct Non-Catecholamine
Use - B2 Selective > B1 with no Alpha for Asthma + COPD
Toxicity - Tachycardia + Tremor + Reduce Uterine Contractions

Question 17

Esomolol - Class + Use + Toxicity

Answer 17

Class - Rapid Acting B1 Beta Blocker (Cardiac
Use - HTN - Arrhythmia + Angina
Toxicity - Low Beta Symp. Activity - AV Block + Heart Failure - with no bronchospasm

Question 18

Major Beta Blocker Uses (6)

Answer 18

1) Angina - Decrease HR/Contractility - Less O2 Demand
2) MI - Cardiac B-Blockers for less death
3) Superventricular Tachycardia - Class II Anti-Arrhythmic - Slows AV Node Conduction
4) HTN - Decrease CO + Renin Secretion
5) CHF
6) Glaucoma - Decreses Aqueous Humor

Question 19

Phentolamine - Class + Use + Toxicity

Answer 19

Class - Non-selective Alpha Blocker - Reversible
Use - Pheochromocytoma
Toxicity - Orthostatic HTN + Reflex Tachycardia

Question 21

Metaprolol - Class + Use + Toxicity

Answer 21

Class -B1 Beta Blocker (Cardiac
Use - HTN - Arrhythmia + Angina
Toxicity - Low Beta Symp. Activity - AV Block + Heart Failure - with no bronchospasm

Question 22

Alpha Adrenergic Blockers - Names (4) + Mechanisms (3)

Answer 22

A1 Selective Blockers - Prazosin + Doxazosin
Non-Selective Reversible - Phentolamine
Non-Selective Irreversible - Phenoybenzamie

Question 22

Atenolol - Class + Use + Toxicity

Answer 22

Class -B1 Beta Blocker (Cardiac
Use - HTN - Arrhythmia + Angina
Toxicity - Low Beta Symp. Activity - AV Block + Heart Failure - with no bronchospasm

Question 23

Prazosin - Class + Use + Toxicity

Answer 23

Class - A1 Selective Alpha Blocker
Use - HTN - Reduce Preload + Afterload via vasodilation without hypotension + BPH
Toxicity - Orthostatic HTN (with first dose) and no tachycardia

Question 24

Amphetamine - Class + Use + Toxicity

Answer 24

Class - Catecholamine Release Symp.
Use - ADHD + Narcolepsy + Anorexia
Toxicity - Paranoia + Aggression + Insomnia + HTN

Question 25

Phenoybenzamine Class + Use + Toxicity

Answer 25

Class - Non-selective Alpha Blocker - Irreversible
Use - Pheochromocytoma
Toxicity - Orthostatic HTN + Reflex Tachycardia