TAG degradation, Fatty Acid Oxidation, Ketone Bodies

Question 1

Chylomicron function

Answer 1

Transports dietary TAG to adipose and other tissues

Question 2

Chylomicron remnant function

Answer 2

Delivers remaining TAG to liver. Exchanges TAG for CE from HDL; delivers CE to the liver

Question 3

VLDL (function)

Answer 3

Transports endogenously synthesized TAG to adipose tissue and to skeletal/heart muscle

Exchanges TAG for CE from HDL

Question 4

IDL - VLDL remnant (function)

Answer 4

Delivers remaining TAG and cholesterol to liver. Exchanges TAG for CE from HDL. Delivers CE to the liver

Question 5

LDL (function)

Answer 5

Delivers cholesterol to the liver and other cells, including steroidogenic cells

Question 6

HDL (function)

Answer 6

Accepts cholesterol from peripheral cells, esterifies it, and transports CE’s to liver

Exchnages CE for TAG in VLDL, IDL, and chylomicron remnants

Question 7

Paraoxonase

Answer 7

HDL enzyme that inhibits LDL oxidation

Question 8

Particle w/ TAG as main lipid

Answer 8

Chylomicrons, chylomicron remnant, VLDL

Question 9

Particle w/ cholesterol as main lipid

Answer 9

LDL, HDL

Question 10

Transporter of dietary (exogenous) lipid

Answer 10

Chylomicrons

Question 11

Transporter of synthesized (endogenous) lipid

Answer 11

VLDL, IDL, LDL

Question 12

Site of synthesis of chylomicrons, Apo A-1, and B-48

Answer 12

Intestines

Question 13

Site of transient gain of Apo-E and C-II from HDL

Answer 13

Plasma

Question 14

Activator of LPL (lipoprotein lipase)

Answer 14

Apo C-II

Question 15

Action of LPL

Answer 15

Catalyzes conversion of TAGs to free fatty acids and glycerol

Question 16

Fate of chylomicron remnants

Answer 16

Removal by liver via receptor-mediated endocytosis

Apo E binds to LDL receptor, LDL receptor-related protein (LRP)

Question 17

HDL serves as repository for _________

Answer 17

Apo C-II, A-I, and E

Question 18

Apo-CII

Answer 18

cofactor, activates lipoprotein lipase

Question 19

Apo-AI

Answer 19

cofactor, activates LCAT (lecithin:cholesterol actyltransferase)

Question 20

Apo E

Answer 20

Binds to LRP; clearance

Question 21

Apo B-100

Answer 21

Binds to LDL receptor; VLDL secretion

Question 22

Apo B-48

Answer 22

structural protein, chylomicron secretion

Question 23

Major pathway for removal of LDL from circulation

Answer 23

Binding of Apo B-100 on LDL to the LDL receptor