T4 Synthesis Flashcards
1
Q
What does T4 synthesis require?
A
Iodine pump and synthesis of thyroglobulin (TG)
2
Q
What turns on iodine pump?
A
TSH, thyroid stimulating hormone
3
Q
What is TG?
A
Thyroglobulin. Consists of tyrosine molecules turned on by TSH.
4
Q
Adding iodine to thyroglobulin requires what?
A
Thyroid peroxidase
5
Q
What is referred to as the organification of iodine?
A
Adding iodine to thyroglobulin
6
Q
What enzyme is selenium dependent?
A
Thyroid peroxidase
7
Q
What do T4 and T3 undergo in synthesis of T4?
A
Receptor mediated endocytosis and released into blood.
8
Q
Are T3 and T4 lipid soluble?
A
Yes.
