Endocrine Signaling, Molecules, And Receptors Flashcards

1
Q

Paracrine signaling?

A

Secreted by cells and impacts only neighboring cells

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2
Q

Endocrine signaling?

A

Secreted by glands into capillary and has target organ far away

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3
Q

Neuroendocrine signaling?

A

Secreted by nerves into capillary and has target organ reached by blood

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4
Q

What is a steroid?

A

Made from a cholesterol. Is lipid soluble and binds to cytoplasmic or nuclear receptors.

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5
Q

What are fat soluble hormones?

A

All steroid and thyroid hormones such as T4 and T3. They bind to either a cytoplasmic or nuclear receptor and lead to transcription and long term effects.

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6
Q

How do, steroids, for example, travel, and what is their impact?

A

Through blood bound to binding proteins. Have different impact in childhood vs adulthood and different impact on different tissues.

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7
Q

What is a peptide?

A

Contains amino acids or amino acid derivatives and bind to cell surface receptors and work through G reactive type proteins.

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8
Q

What is not a peptide bc it acts like a steroid?

A

Thyroxine. T4.

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9
Q

How do peptide hormones work?

A

Have cell surface receptors and work by intercellular signaling.

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10
Q

The majority of hypothalamic-pituitary hormones are what kind of hormone?

A

Peptide hormone.

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11
Q

Name basophils.

A

Corticotropes.
Thyrotropes.
Gonadotropes.

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12
Q

Name acidophils.

A

Lactotropes.
Somatotropes.

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13
Q

Corticotropes?

A

Adrenocorticotropic hormone (ACTH)

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14
Q

Thyrotropes?

A

Thyroid stimulating hormone (TSH)

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15
Q

Gonadotropes?

A

Follicle stimulating hormone (FSH) and leutinzing hormone (LH)

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16
Q

Lactotropes?

A

Prolactin

17
Q

Somatotropes?

A

Growth hormone (GH)

18
Q

What does ADH do and why is it different from oxytocin?

A

Constricts blood vessels and differs in structure by only 2 amino acids

19
Q

Name hormones from posterior pituitary?

A

Vasopressin (ADH)
Oxytocin

20
Q

Hormone of anterior pituitary?

A

Prolactin

21
Q

What causes conversion of testosterone to estradiol?

A

Aromatase.

22
Q

What highly binds to plasma proteins?

A

Steroid and thyroid hormones.

23
Q

What hormones are water soluble and not highly bound by plasma proteins?

A

Peptide

24
Q

What hormone is virtually unbound by plasma proteins?

A

ADH, a neurohypophysial peptide hormone

25
Q

Thyroid hormones and peptide hormones have appreciable stores in their endocrine producing glands, what kind of hormone is not stored in appreciable extend in endocrine producing glands?

A

Steroids.