T2DM drugs

Question 1

What T2DM drugs cause weight gain?

Answer 1

Sulphonylurea
Pioglitazone
Insulin

Question 2

What drugs cause weight loss?

Answer 2

Metformin
SGLT2 inhibitor
GLP-1 agonist

Question 3

What has a higher efficacy and what is used first, DPP-4 inhibitors or GLP-1 agonists?

Answer 3

GLP-1 has higher efficacy

DPP-4 is used first

Question 4

What drugs have cardiovascular benefit?

Answer 4

Metformin

SGLT-2 inhibitors

Question 5

What drugs carry hypoglycaemia risk?

Answer 5

Sulphonylureas

Insulin

Question 6

What drugs have moderate efficacy?

Answer 6

Metformin
SGLT2 inhibitors
DPP-4 inhibitors (low/moderate)
Pioglitazone

Question 7

What drugs have high efficacy?

Answer 7

Sulphonylureas
GLP-1 agonists
Insulin

Question 8

What is the main adverse effect of metformin?

Answer 8

GI

Question 9

What is the main adverse effect of SUs?

Answer 9

Hypoglycaemia

Question 10

What is the main adverse effect of SGLT2 inhibitors?

Answer 10

Genital infection

Question 11

What is the main adverse effect with DPP-4 inhibitors?

Answer 11

Few (can cause headache)

Question 12

What is the main adverse effects of pioglitazone?

Answer 12

Oedema

Fractures

Question 13

When you use insulin in T2DM, is it the same regimen as T1DM?

Answer 13

No, use basal to start with.

If need more than that refer to a specialist to add in mealtime insulin.

Question 14

What drugs are oral?

Answer 14

Metformin
SUs
SGLT-2 inhibitors
DPP-4 inhibitors
Pioglitazone

Question 15

What drugs are injectable?

Answer 15

GLP-1 agonists

Insulin

Question 16

What is the main adverse effect of GLP-1 agonists?

Answer 16

Gastrointestinal

Question 17

What drugs can be used in CKD and what is the warnings associated?

Answer 17

Metformin (max 2g daily)
SU (careful monitoring)
DPP-4 (reduce dose)
Pioglitazone (dose unchanged)
GLP-1 agonist (dose unchanged)
Insulin (dose unchanged)

Question 18

What drug cannot be used in CKD?

Answer 18

SGLT-2 inhibitors