T2 L6: Anatomy and function of basal ganglia Flashcards

1
Q

Which structures make up the basal ganglia?

A

The caudate nucleus, thalamus, putamen, globus pallidus, and the red nucleus

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2
Q

What is the globus pallidus split into?

A

Into pars externa and pars interna

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3
Q

Which structures is the Pallidum made up of?

A

The internal and external Globus pallidus

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4
Q

Which structures is the Lentiform nucleus made up of?

A

The putamen and globus pallidus

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5
Q

Which structures is the corpus striatum made up of?

A

Caudate nucleus, putamen, and pallidum

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6
Q

What divides the structures within the corpus striatum and what is it made up of?

A

It’s divided by the internal capsule made up of ascending and descending tracts (white matter)

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7
Q

Which structures is the neostriatum made up of?

A

The caudate nucleus and putamen

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8
Q

What is the nucleus Accumbens for?

A

It mediates reward behaviour and addiction

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9
Q

What are the 4 basal ganglia loops?

A

Motor, oculomotor, prefrontal, and limbic

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10
Q

What the direct pathway for?

A

To promote movement

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11
Q

Which structures are involved in the direct pathway?

A

The cortex, striatum, internal globus pallidus, and the thalamus

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12
Q

What is the indirect pathway for?

A

To withhold movement

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13
Q

Which structures are involved in the indirect pathway?

A

The cortex, striatum, external globus pallidus, subthalamic nucleus, internal globus pallidus, and the thalamus

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14
Q

What is the hyperdirect pathway for?

A

As an emergency stop

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15
Q

Which structures are involved in the hyperdirect pathway?

A

The cortex, subthalamic nucleus, internal globus pallidus, and the thalamus (it bypasses the striatum and the external globus pallidus

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16
Q

What effect does the cortex have on the striatum?

A

Excitatory

17
Q

What effect does the striatum have?

A

Inhibitory

18
Q

What effect does the thalamus have in the cortex?

A

Excitatory

19
Q

What effect does inhibiting the thalamus have?

A

Prevents movement

20
Q

What effect does reducing the inhibition of the thalamus have?

A

Facilitates movement

21
Q

What substance does the substancia nigra release?

A

Dopamine

22
Q

What effect does dopamine have on direct (D1) medium spiny neurones?

A

Increases their excitation

23
Q

What effect does dopamine have on indirect (D2) medium spiny neurones?

A

Decreases their excitation

24
Q

What is the function of interneurons?

A

They tune transmission

25
Q

Which molecule opposes the effects of dopamine when it comes to striatum neurones ?

A

Acetylcholine

26
Q

How are the different pathways of the striatum balanced?

A

Through the activity of 2 medium spiny neurones which are influenced by dopamine and acetylcholine