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Pharmaceutics > T1 - Final Exam: Fincher > Flashcards

T1 - Final Exam: Fincher Flashcards

1
Q

What is the route of administration for the eye surface?

A

Ophthalmic

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2
Q

What is the route of administration for the epidermal surface?

A

Trasdermal

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3
Q

What is the route of administration for the veins?

A

Intravenous injection or infusion

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4
Q

What is the route of administration for the subcutaneous fat?

A

Subcutaneous

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5
Q

What is the route of administration for between the cheek and gum?

A

Buccal

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6
Q

What is the route of administration for the mouth (inhaled)?

A

Pulmonary

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7
Q

Which of the following are the two most common ways in which we measure drug concentrations in humans?

A

Urine and Plasma

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8
Q

What is pharmaceutics?

A

Examines the physiochemical properties of drugs and dosage forms as it relates to dosage form design

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9
Q

What is biopharmaceutics?

A

Examines the interrelationship between the physicochemical properties of drugs, the dosage form, and the route of administration on the rate and extent of drug absorption into the body

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10
Q

What is pharmacokinetics?

A

Studies the movement of drugs within the body

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11
Q

What is LADME?

A

Liberation, Absorption, Distribution, Metabolism, Excretion

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12
Q

What is the quantitative measurement of drugs?

A

Blood pressure and cholestrol

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13
Q

What is the qualitative measurement of drugs?

A

Subjective, measure of pain

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14
Q

What is bioavailability?

A

Proportion (percent or fraction) of an administered dose of unchanged drug that reaches the systemic circulation

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15
Q

What is clearance?

A

The volume of plasma cleared of drug per unit time

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16
Q

What is half-life?

A

The time required for plasma concentration of drug to decrease by 50%.

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17
Q

What is volume of distribution?

A

An indicator of how well distributed a drug is in the body

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18
Q

What is liberation?

A

Release of the drug from its dosage form

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19
Q

Where is drug typically absorbed?

A

Into the bloodstream

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20
Q

How are drugs metabolized?

A

By enzymes

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21
Q

How much is the difference between the distribution of intracellular and extracellular?

A

Intracellular is doubled than extracellular

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22
Q

What is Schedule I drug?

A

Drugs with no accepted medical use, or other substances with a high potential for abuse

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23
Q

What are examples of schedule 1 drug?

A

LSD, mescaline, peyote, methaqualone, marijuana, heroin

24
Q

What is Schedule II?

A

Drugs with accepted medical uses and a high potential for abuse that if abused may lead to severe psychologic or physical dependence

25
Q

What are examples of Schedule II?

A

Morphine, cocaine, methamphetamine, amobarbital, and other such drugs

26
Q

What is Schedule III drug?

A

Drugs with accepted medical uses and a potential for abuse less than those listed in schedules I and II that if abused may lead to moderate psychologic or physical dependence.

27
Q

What is an example of Schedule III?

A

Codeine, butalbital, testosterone

28
Q

What is a Schedule IV drug?

A

Drugs with accepted medical uses and low potential for abuse relative to those in schedule III that if abused may lead to limited physical dependence or psychologic dependence relative to drugs in schedule III

29
Q

What is an example of a schedule IV drug?

A

Difenoxin, diazepam, oxazepam, and similar agents

30
Q

What is a Schedule V drug?

A

Drugs with accepted medical uses and low potential for abuse relative to those in schedule IV that if abused may lead to limited physical dependence or psychologic dependence relative to drugs in schedule IV

31
Q

What is an example of a Schedule V?

A

Dihydrocodeine, diphenoxylate, and similar agents

32
Q

What are the components of an NDC number?

A

1st segment: Drug’s manufacturer
2nd segment: Product
3rd segment: Packaging (size and quantity)

33
Q

What is Class I of drug product recall?

A

There is a reasonable probability that the use of or exposure to a violative product will cause serious adverse health consequences or death.

34
Q

What is Class II of drug product recall?

A

The use of or exposure to a violative product may cause temporary or medically reversible adverse health consequences or the probability of serious adverse health consequences is remote

35
Q

What is Class III of drug product recall?

A

The use of or exposure to a violative product is not likely to cause adverse health consequences

36
Q

What is isotonic solution?

A

A solution having the same osmotic pressure as the specific body fluid

37
Q

What is hypertonic solution?

A

Solutions of higher osmotic pressure than that of a body fluid causing the cell to shrink or crenate

38
Q

What is a hypotonic solution?

A

Solutions of lower osmotic pressure than that of a body fluid causing the cell to lysis or swelling

39
Q

What is the behaviors of non electrolytes in a non aqueous solution?

A

Behaves as a ideal solution

40
Q

What is the behaviors of a strong electrolytes in a non aqueous solution?

A

Ions pair

41
Q

What is the behaviors of a weak electrolytes in a non aqueous solution?

A

Behave as a ideal solution

42
Q

What is the behaviors of a weak electrolytes in an aqueous solution?

A
  1. Weak current
  2. Partially ionized
  3. Colligative properties based on ionization
  4. Weak acids, weak bases, benzoic acid, atropine
43
Q

What is the behaviors of a strong electrolytes in an aqueous solution?

A
  1. Conduct strong current
  2. Totally ionized
  3. Exhibit irregular colligative properties
  4. Mineral acids, strong bases, all salts
44
Q

What is the behaviors of non electrolytes in an aqueous solution?

A
  1. Do not conduct current
  2. No ions present
  3. Exhibit regular colligative properties
  4. Sugars, alcohols, acetamide, acetone, glycerin
45
Q

What are the 4 colligative properties?

A
  1. Osmotic Pressure
  2. Vapor Pressure Lowering
  3. Freezing Point Depression
  4. Boiling Point Elevation
46
Q

What is a colligative property?

A

The physical properties of solutions vary according to the concentration of the dissolved solute

47
Q

What is osmotic pressure?

A

The pressure created when solvent passes through a semipermeable membrane from a dilute solution into a more concentrated one

48
Q

What is the the osmotic pressure created by a non electrolyte?

A

Only the concentration affect the pressure

49
Q

What is the the osmotic pressure created by an electrolyte?

A

Dissolution and concentration affect pressure

50
Q

What is the relationship between solutes and pressure?

A

Solutes that dissociate have greater number of particles in solution and exert a greater osmotic pressure than undissociated ones

51
Q

Which of the following molecules will exert the largest freezing point depression, non-electrolyte or electrolyte?

A

Nonelectrolyte

52
Q

What are the primary anions and cations in plasma?

A

Na+ and Cl-

53
Q

What are the primary anions and cations in ECF?

A

Na+ and Cl-

54
Q

What are the primary anions and cations in ICF?

A

K+ and HPO4-

55
Q

What is the ideal body osmolarity?

A

300 +/-

Pharmaceutics (27 decks)

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