T+O Flashcards
Osteoarthritis (OA)
- wear + tear of joints
- loss of cartilage, osteophyte formation, inflammation
- hips, knees, DIPJ, CMC base of thumb, lumbar spine, c-spine
OA Px
- joint pain
- stiffness, <30mins morning, worse after activity
- reduced ROM
- crepitus
- effusions
- bulky/bony enlargement of joint
Hands
- Heberdens nodes - DIPJ
- Bouchards nodes - PIPJ
- DIPJ>PIPJ
- Squaring at base of thumb (CMC joint)
- weak grip, reduced ROM
OA Ix
Dx
- > 45yo, typical pain, <30mins morning stiffness
XR - LOSS
Loss of joint space
Osteophytes
Subarticular sclerosis
Subchondral cysts
Oxford Hip Score
OA Mx
- OT/PT, lose weight, exercise
- topical NSAIDs
- oral NSAIDs (+PPI)
- weak opiates, paracetamol - short-term
- intra-articular steroid injections
- arthroplasty
Hip replacement Cx
- VTE, intraoperative fracture, nerve injury, infection
- Leg length discrepancy
- posterior dislocation
- aseptic loosening
- prosthetic joint infection
XR interpretation
Initial approach
- patient details, XR details
- adequacy - 2 views, joint above+below, rotation, penetration
- previous imaging
ABCS approach
- alignment, joint space
- bone texture
- cortices
- soft tissues
- what bone, area, articular surface involvement
- type of fracture
Types of fractures
COMPLETE – fracture extends all the way through bone
- Closed – no break in skin
- Open – break in skin
- Transverse – right angle to shaft
- Oblique – angle to shaft
· Eg Toddler’s fracture – oblique tibial fracture in infants
- Spiral – twisting
- Segmental – more than one fracture along bone
- Comminuted – 2+ bone fragments
- Compression – involving vertebrae in spine
- Impacted – fractured bone forced together
INCOMPLETE (not all the way through cortex) – commonly children
- Greenstick – bending of shaft, fracture on convex surface
- Buckle (torus) – fracture of shaft of bone characterised by bulging of cortex
- Salter-Harris – involving growth plate
- Bowing – bend in bone shaft – plastic deformity
Fracture displacement
- Describe in terms of distal fragment to body (eg anterior/posterior)
- Angulation – change in axis of bone – dorsal / palmar, varus/valgus, radial/ulnar
- Translation – movt of fractured bones away from each other – use width of bone, eg 25% - if >100% - describe as off-ended
- Rotation – difficult to see on XR
Fracture causes
- trauma - excessive force
- stress-related - repetitive low velocity injury
- pathological - abnormal bone, fractures during normal use
Fracture healing
- Haematoma formation, dead bone removed
- Fibrocartilaginous callus formed, then bony callus, then replaced by trabecular bone
- Remodelled into lamellar bone
- Fracture healing delayed if bone ends are mobile, infected, misaligned, avascular
Fracture Px
- pain
- deformity
- loss of function
Fracture Ix
- check for other injuries
- NV status of limb
- XR - 2 views, inc joint above + below
- CT +/- angio maybe
Fracture Mx
- immobilise, inc joints above + below
- reduce if necessary
- analgesia
- open - IV abx, tetanus, debride + lavage <6hrs, avoid internal fixation
- simple - fracture clinic follow up
- complex - NBM, add to trauma list for morning
- mechanical alignment - manipulation / surgery
- stability - casts, wires/plates/screws, ORIF, external frame
- rehab early
Fracture Cx
Early
- damage to local structures
- haemorrhage
- compartment syndrome
- fat embolism
- VTE
Long-term
- delayed union, malunion, non-union, avascular necrosis, osteomyelitis, joint instability, stiffness, arthritis, chronic pain
Paediatric fractures
Complete – both sides of cortex breached
Toddler’s fracture – oblique tibial fracture in infants
Bowing – plastic deformity, no break
Greenstick fracture – bending of shaft, fracture on convex surface
Buckle / torus fracture – incomplete cortical disruption resulting in periosteal haematoma
Growth plate fractures – fracture of growth plate – Salter-Harris classification
Paediatric fractures NAI
- Delayed presentation
- Delay in attaining milestones
- Lack of concordance between proposed and actual mechanism of injury
- Multiple injuries
- Injuries at sites not commonly exposed to trauma
- Children on the at risk register
Paediatrics pathological fractures
eg osteogenesis imperfecta
Fat embolism
- fat globule released into circulation after long bone fracture
- lodges in pulm arteries
- causes systemic inflammatory response
Fat embolism Px
- 24-72hrs after fracture
Gurd’s major criteria
- Respiratory distress
- Petechial rash
- Cerebral involvement – confusion, agitation
Gurd’s minor criteria
- Jaundice, thrombocytopenia, fever, tachycardia, retinal haemorrhages,, renal signs, high ESR, anaemia….
Fat embolism Ix
- imaging may be normal
- CTPA - may not show occlusion
Fat embolism Mx
- supportive
- operate early to reduce risk
- VTE prophylaxis
Compartment syndrome
- high pressure in fascial compartment - cuts off blood supply
- associated with fracture / crush injury - bleeding/swelling in compartment
- restrict capillaries, then venous, then arterial - ischaemia + necrosis
Compartment syndrome Px
- pain - disproportionate
- paraesthesia
- pale - initially warm + swollen
- pressure high
- paralysis - late
Compartment syndrome Ix
- clinical dx
- needle manometry
Compartment syndrome Mx
- remove dressings, elevate to heart level
- emergency fasciotomy
Osteomyelitis
- infection of bone
Osteomyelitis patho
- S aureus most commonly (salmonella in SCA)
Haematogenous
- from blood infection
- eg vertebral osteomyelitis
- RFs - SCA, IVDU, immunosuppression, IE
Contigous
- from adjacent tissues
- RFs - diabetic foot ulcers, pressure sores, DM, PAD
Direct inoculation
- direct trauma / surgery
- RFs - open fractures, surgery
Osteomyelitis Px
- fever, rigors, sweats, malaise, N+V
- dull pain, tender, warm, erythema, swelling
- maybe non-healing ulcers, non-healing fractures
Osteomyelitis Ix
- Bloods - cultures, FBC, CRP
- XR - potential periosteal reaction, osteopenia, bone destruction
- MRI
- Bone cultures
Osteomyelitis Mx
Abx
- flucloxacillin 6wks (clindamycin)
- +/- rifampicin/fusidic acid for first 2wks
- vancomycin/teicoplanin MRSA
- chronic - >3mo abx
Surgery
- debridement, hardware removal
Septic arthritis
- infection in joint
- rapidly destroys joint, systemic illness
- S aureus most commonly
- also N gonorrhoea, H influenzae, E coli
RFs
- prosthetic joints, DM, immuno, RA, low SES, IVDU, osteomyelitis, surgery, joint injections
Septic arthritis Px
- Single joint, often knee
- Hot, red, swollen
- Stiff, reduced ROM
- Non-weight bearing
- Fever, lethargy
- Sepsis sx
Septic arthritis Ix
- joint aspiration - to MC+S, gram staining, crystal microscopy
- FBC - raised WCC, CRP
- Blood cultures
- STI screen, HIV
- XR joint
Septic arthritis Mx
- empirical IV abx, then continue for 4-6wks (oral after 2wks)
- flucloxacillin / clindamycin
- vancomycin - MRSA
- ceftriaxone - gonorrhoea
- arthroscopic lavage
Sarcoma
malignant tumour originating from mesenchymal (connective) tissue
Bone sarcomas
osteosarcoma
chondrosarcoma
Ewing’s sarcoma
Osteosarcoma
- most common primary malignant bone tumour
- mainly children, adolescents
- mostly metaphyseal region of long bones
- XR - Codman triangle, sunburst pattern
Chondrosarcoma
- malignant tumour of cartilage
- middle-aged
- axial skeleton
Ewing’s sarcoma
- small round blue cell tumour
- children/adolescents
- from mesenchymal stem cells
- pelvis, long bones
- severe pain
- XR - onion skin appearance
Soft tissue sarcoma
Liposarcoma – from adipose
Rhabdomyosarcoma – skeletal muscle
Synovial sarcoma – from soft tissue around joints
Fibrosarcoma
Angiosarcoma – blood and lymph vessels
Leiomyosarcoma – smooth muscle
Kaposi’s sarcoma – cancer caused by HHV 8, mostly seen in end-stage HIV
Bone tumours patho
- primary bone tumours rare - would mets to lung
- most commonly secondary - osteolytic - mets from breast, prostate, kidney, lung, thyroid
Benign bone tumours
Osteoma
- benign overgrowth of bone
Osteochondroma
- cartilage-capped bony projection on external surface of bone
- metaphysis of long bones
Giant cell tumour
- tumour of multinucleated giant cells in fibrous stroma
- epiphysis of long bones
- XR - double bubble / soap bubble appearance
Osteoblastoma / osteoid osteomas
- from osteoblasts
Bone tumour Px
- depends on location / size
- pain, swelling, palpable mass
- impaired function
- pathological fractures
- fatigue, wt loss, fever, anaemia
- aches/pains - hypercalcaemia
Bone tumour Ix
- Scans - XR, CT, MRI, PET, skeletal isotope scan
- USS for soft tissue lumps
- Biopsy - fine needle / core / incisional
- TNM staging
- Bloods - high Ca, ALP
Bone tumour Mx
- surgical resection
- radio/chemo
- targeted therapy
- immunotherapy
- hormonal therapy
- bisphosphonates - alendronate
Osteochondritis dissecans (OCD)
- pathological process affecting subchondral bone - secondary effects on joint cartilage
- bone fragments, creates defect between lesion + parent bone, lack of blood supply to fragment
- pain, oedema, free bodies, degenerative changes if untreated
OCD Px
- subacute
- knee pain, swelling, after exercise
- catching, locking, giving way
- painful click flexing / extending knee
…
OCD Ix
- XR - subchondral crescent sign, loose bodies
- MRI
OCD Mx
Non-surgical
- Modify activity
- Partial / non-weight bearing
- Immobilise – promote healing
Surgical
- Arthroscopic drilling
- Pins to secure flap
- …
Rib fracture
- may have underlying injury / flail chest
RFs
- blunt trauma
- osteoporosis, steroids, COPD
- pathological - cancer
Px
- severe, sharp chest wall pain, tenderness
- bruising
- haemopneumothorax
Ix
- CT chest
- CXR
Mx
- pain control
- surgical fixation
- Mx cx, consider ventilation
Lower back pain (non-specific)
- pain in lumbosacral region, no specific cause
- aka mechanical back pain
- may come from pathology of vertebrae, facet joints, intervertebral discs, muscles / ligaments
RFs
- obesity, sedentary, heavy lifting, stress, depression, low SES, smoking
Lower back pain (non-specific) Px
- Pain in lower back
- Exacerbated by movt
- Varies with time and posture
- No red flag features
Back pain DDx
- Cauda equina
- Spinal fracture
- malignancy
- spinal infections - discitis, vertebral osteomyelitis, epidural abscess
- spinal stenosis
- radicular pain
- radiculopathy
- spondylolisthesis
- OA of spine
- facet joint pathology
- aseptic necrosis of femoral head
- pyelo, renal stones, prostatitis, PID, endometriosis, pancreatitism PAD, AAA
Back pain red flags
- <20yo, >50yo
- Hx of malignancy
- Nocturnal pain
- Hx of trauma
- Systemically unwell - fever, weight loss, night sweats
- IVDU
- Immunocompromise - eg HIV, meds
- Bilateral leg pain, neuro deficits
- Urinary incontinence / retention
- Faecal incontinence
- Early morning stiffness or at rest
- Current / recent infection - TB, staph etc
- Abdo mass - malignancy
- Acute onset in elderly - osteoporotic
- Pain when lying down (usually resolves pain)
- Leg claudication
Back pain Ix
- bloods - CRP, WCC, FBC, U/E, ESR, bone, LFTs
- urine dip
- MRI
- spinal XR
- STarT back tool- bloods - CRP, WCC, FBC, U/E, ESR, bone, LFTs
- urine dip
- MRI
- spinal XR
- STarT back tool
Back pain Mx
- exercise, heat
- NSAIDs + PPI
- codeine +/- paracetamol (short term)
- diazepam - muscle spasms
- physio
- massage
- CBT
- radiofrequency denervation
Prolapsed L3 disc
- Sensory loss anterior thigh
- Weak hip flexion, knee extension, hip adduction
- Reduced knee reflex
- Positive femoral stretch test
Prolapsed L4 disc
- Sensory loss anterior knee, medial malleolus
- Weak knee extension, hip adduction
- Reduced knee reflex
- Positive femoral stretch test
Prolapsed L5 disc
- Sensory loss dorsum of foot
- Weakness in foot / big toe dorsiflexion
- Reflexes intact
- Positive sciatic nerve stretch test
Prolapsed S1 disc
- Sensory loss posterolateral aspect of leg, lateral aspect of foot
- Weakness in plantarflexion of foot
- Reduced ankle reflex
- Positive sciatic nerve stretch test
Disc prolapse Px
- back pain
- dermatomal leg pain
- worse when sitting
- sensory/motor deficit
Disc prolapse Mx
- analgesia (NSAIDs), physio, exercises
- if sx >4-6wks, consider MRI
Spinal stenosis
- narrowing of central canal in spine - compresses spinal cord / nerve roots
- from tumour, disc prolapse, degenerative changes
Spinal stenosis Px
- gradual onset
- lower back pain, buttock pain
- neuropathic pain, leg weakness
- sciatica / radiculopathy
- sx better when sitting
- easier walking uphill than downhill
- struggle sitting on bike
Spinal stenosis Ix
- MRI spine
- R/o PAD - ABPI, CT angio
Spinal stenosis Mx
- exercise, wt loss, physio
- surgery - laminectomy
Sciatica
- irritation / compression of sciatic nerve
- eg herniated disk, spinal stenosis, spondylolisthesis, piriformis syndrome…
- L4-S3 form sciatic, sensation to lateral lower leg, foot, motor to posterior thigh, lower leg, foot
Sciatica Px
- unilateral shooting pain from buttock, radiating down back of thigh to knee/foot
- paraesthesia, numbness, weakness
- may affect reflexes
Sciatica Ix
- sciatic stretch test
Sciatica Mx
- physio, exercise, simple analgesia
- consider amitriptyline, duloxetine
- specialist mx - epidural corticosteroid injections, LA injections, radiofrequency denervation, spinal decompression
Cauda equina syndrome (CES)
- compression of cauda equina - surgical emergency
- spinal cord terminates L2/3
Causes
- herniated disc
- tumours
- spondylolisthesis
- abscess
- trauma
CES Px
- low back pain
- bilateral sciatica / weakness, numbness, paraesthesia
- loss of sensation in bladder/rectum
- saddle anaesthesia
- urinary retention / incontinence
- faecal incontinence
- gait disturbance / difficulty walking
- reduced anal tone (PR)
- reduced tone / reflexes
CES Ix
- urgent MRI
CES Mx
- neurosurgical - lumbar decompression surgery
Discitis
- infection of intervertebral disc space
- S aureus most commonly
Discitis Px
- back pain
- fever, rigors, sepsis
- if epidural abscess develops - lower limb neurology
Discitis Ix
- MRI
- CT guided biopsy
- bloods, inc cultures
- ECHO - IE
Discitis Mx
- 6-8wks IV abx
Osteoporotic vertebral fracture
- spinal fracture in osteoporosis
RFs for osteoporotic fractures
- older
- post-menopause
- Hx of fragility #
- Hx of falls
- steroids
- FHx NOF
- secondary osteoporosis
- low BMI
- smoking, drinking
Osteoporotic vertebral fracture Px
- asym
- acute back pain
- breathing difficulties, GI problems
- Hx fall / trauma - minority
- loss of height, kyphosis
- localised tenderness