Opthalmology Flashcards
Glaucoma
Optic nerve damage from rise in IOP
Glaucoma patho
- Imbalance in aq humour production / drainage - usually blockage
- increased pressure on retina / optic nerve - damage to peripheral retina first, then central, cupping of optic disc
- normal pressure 10-21 mmHg
Open angle glaucoma
- chronic
- degeneration of trabecular meshwork -> increased resistance -> increased IOP, degeneration of optic nerve
RFs
- older, FHx, black, myopia (near sighted)
Open angle glaucoma Px
- asym - dx on screening
- tunnel vision (lose peripheries)
- pain
- headaches
- blurred vision
- halos around lights (worse at night)
Open angle glaucoma Screening
- strong FHx - every 2yrs from 30yo
- every 5yrs >40yo, every 2yrs >60
Open angle glaucoma Ix
Fundoscopy
- optic disc cupping - ratio >0.5
- pale disc - atrophy
- vessel bayonetting
- haemorrhage at risk
- vertical thinning
Visual field assessment
- loss of peripheral vision
Non-contact tonometry
- puff of air, estimate IOP (raised)
Goldmann applanation tonometry
- gold std for IOP - device on slit lamp in contact with cornea
Open angle glaucoma Mx
- start when IOP >24
- 360-degree selective laser trabeculoplasty
- Latanoprost eye drops - prostaglandin
- Timolol - BB
- Acetazolamide - carbonic anhydrase inhibitor
- Brimonidine - sympathomimetics
- Trabeculectomy
- plastic tube shunt
- Inform DVLA
Acute angle closure glaucoma (AACG)
- acutely raised IOP from physically obstructed outflow (iridocorneal angle)
Pupillary block
- lens pushes against iris, blocks aq humour flow through pupil, iris / lens pushed anteriorly - closes iridocorneal angle + blocks trabecular meshwork
Closure of outflow angle
- pupil dilates, iris thickens, IC angle reduces, can close spontaneously
- retina damaged from stretching, decreased blood supply
RFs
- hyperopic (far-sighted) - shallow anterior chambers
- older, F>M, FHx, Chinese
- meds causing pupil dilation - antihistamines
AACG Px
- red, painful eye
- N+V, headache
- halo around lights
- sx worse with pupil dilatation - eg will be watching TV in dark room
- pupil sluggish + dilated
- eye hard to palpation
- reduced visual acuity
- hazy cornea (oedema)
AACG Ix
- tonometry - IOP >60
- gonioscopy - look at angle (lens on slit lamp)
AACG Mx
- lie on back w/o pillow, urgent ophthal referral
- timolol - topical BB
- prednisolone
- oral/IV acetazolamide
- oral glycerol + IV mannitol
- pilocarpine - miotic eye drops
- analgesia +/- antiemetics
- laser iridotomy - both eyes
Age-related macular degeneration (ARMD)
Degeneration of macula (central retina) -> blindness
ARMD Patho
Degeneration of retinal photoreceptors, formation of drusen, atrophy of retinal pigment epithelium
Dry / atrophic - 90% - early
Drusen, changes in pigmentation of retinal pigment endothelium
Wet / exudative - 10% - late
choroidal neovascularisation, VEGF, oedema, rapid vision loss
RFs
older, F>M, smoker, FHx, IHD, HTN, dyslipidaemia, DM
ARMD Px
- reduction in visual acuity - near field / central
- worse vision at night
- day to day change in vision
- photopsia - flashing lights
- glare around objects
- visual hallucinations -> Charles-Bonnet syndrome
ARMD Ix
- Snellen - reduced acuity
- Amsler grid testing - line crooked
- Fundoscopy - Drusen, red patches in wet ARMD
- Slit lamp - pigmentary/exudative/haemorrhagic changes
- colour fundus photography
- fluorescein angiography
- indocyanine green angiograph - see choroidal circulation
- optical coherence tomography (OCT) - 3d retina
ARMD Mx
- stop smoking, control BP
- zinc, vit A, C, E
- Anti-VEGF
- laser photocoagulation (risk of acute visual loss)
Diabetic retinopathy
Retinal deterioration from blood vessel damage due to high blood sugar levels
Diabetic retinopathy Px
- painless reduction of central vision
- dark painless floaters - haemorrhages
- painless visual loss - severe haemorrhage
Diabetic retinopathy Ix
- visual acuity
- spots in red reflex - vitreous haemorrhage
- fundoscopy
- dilated retinal photography + ophthalmoscopy
- OCT / fluorescein angiography
Diabetic retinopathy Mx
- optimise BMs, BP, lipids, healthy diet, stop smoking
maculopathy
- anti-VEGF
non-proliferative
- observation / panretinal laser photocoagulation
Proliferative
- panretinal laser photocoagulation
- anti-VEGF
Vitreous haemorrhage
- vitreoretinal surgery
Diabetic retinopathy fundoscopy
Blot haemorrhages
Hard exudates
Microaneurysms
Venous beading
Cotton wool spots
Intraretinal microvascular abnormalities
Neovascularisation
Diabetic retinopathy classification
Non-proliferative
- Mild - 1+ microaneurysms
- Moderate - microaneurysms, blot haemorrhages, hard exudates, cotton wool spots, venous beading
- Severe - blot haemorrhages + microaneurysms in 4 quadrants, venous beading in 2 quadrants, IMRA in any quadrant
Proliferative
- neovascularisation
- fibrous tissue
- vitreous haemorrhage
Diabetic maculopathy
- macular oedema
- ischaemic maculopathy
- hard exudates
Diabetic retinopathy Cx
Retinal detachment
Vitreous haemorrhage
Rebeosis iridis - new blood vessel formation in iris
Optic neuropathy
Cataracts
Hypertensive retinopathy
damage to small blood vessels in retina from systemic HTN
Hypertensive retinopathy Px
- can be asym
- double vision / blurred vision / reduced acuity / visual field defects
- headaches
- eye pain
- N+V
- end organ damage - HF, AKI, chest pain
Hypertensive retinopathy Ix
- BP
- fundoscopy
- OCT / fluorescein angiography
Hypertensive retinopathy fundoscopy
- silver / copper wiring
- AV nipping
- cotton wool spots
- hard exudates
- retinal haemorrhages
- papilloedema
Hypertensive retinopathy Keith-Wagener classification
Stage 1 - mild narrowing of arterioles, increased light reflex (silver wiring)
Stage 2 - focal constriction of blood vessels + AV nipping
Stage 3 - cotton wool exudates, flame + blot haemorrhages (may collect around fovea - macular star)
Stage 4 - papilloedema
Hypertensive retinopathy Mx
- control BP
- stop smoking
- control lipids
Cataracts
- lens opacifies
- lens fibres aggregate, deposit, cause clouding
Causes
smoking, alcohol, age, trauma, DM, long-term steroids, radiation, myotonic dystrophy, hypocalcaemia
Cataracts Px
- gradual onset, asymmetrical
- reduced visual acuity
- faded colour vision
- starbursts around lights - at night
- loss of red reflex
- white/brown lens when light shone on eye
Cataracts Ix
- ophthalmoscopy - normal fundus / optic nerve
- slit lamp
Cataracts Mx
- surgery
- stronger glasses, brighter lights in meantime
Cataracts surgery cx
- posterior capsule opacification
- retinal detachment
- posterior capsule rupture
- endophthalmitis - inflammation of aq/vit humour - intravitreal abx to tx
Blepharitis
- inflammation of eyelid margins
Causes
- meibomian gland dysfunction - lack of oil, drying of eyes
- seborrhoeic dermatitis / staph infection
Px
- bilateral
- gritty, sticky eyes
- red eyelid margins
- swollen - staph
Mx
- hot compress
- lid hygiene - cotton wool buds, warm water, baby shampoo
- artificial tears - dry eyes
Stye
- painful red lump on eyelid edge - like acne
Types
External - infection of glands of zeis / moll
Internal - infection of meibomian glands
Px
external - tender red lump along eyelid +/- pus
internal - deeper, more painful, may point inwards
Mx
- hot compress
- analgesia
- topical abx if conjunctivitis
Chalazion
- meibomian gland blocked - meibomian cyst
Px
- swelling in eyelid
- may be painless / tender
- red
Mx
- hot compress
- analgesia
- topical abx if inflamed
- surgical drainage if the above fails
Entropion
- eyelid turns in
Mx
- tape eyelid down, eye drops to prevent eye drying
- surgery - definitive
- same day ophthal referral if risk to sight
Ectropion
- eyelid turns out, usually bottom
Mx
- mild - no tx
- eye drops
- surgery
- same day ophthal referral if risk to sight
Trichiasis
- inward growth of eyelash
Px
- painful
- red, watery eye
- feels like FB in eye
Mx
- remove eyelash
- electrolysis, cryotherapy, laser tx if recurrent growth
- same day referral if risk to sight
Abnormal pupil shape causes
- trauma, eg cataracts surgery
- anterior uveitis - adhesions
- AACG - vertical oval shape
- rubeosis iridis - neovascularisation of iris
- coloboma - congenital malformation
- tadpole pupil - spasm in iris - migraines
Mydriasis causes
- 3rd nerve palsy
- Homes-Adie syndrome
- raised ICP
- congenital
- trauma
- phaeochromocytoma
- drugs - atropine, cocaine, amphetamines, TCAs
Miosis causes
- Horner syndrome
- cluster headaches
- Argyll-Robertson pupil
- opiates
- nicotine
- pilocarpine
3rd nerve palsy
- ptosis
- dilated pupil
- divergent strabismus - down + out eye
Causes
- idiopathic
With sparing of pupil (microvascular - psym fibres spared):
- DM, HTN, ischaemia
Full palsy - compression
- tumour, trauma, cavernous sinus thrombosis, PCA aneurysm, raised ICP
Horner syndrome
- damage to sympathetic nerves system supplying face
- ptosis, miosis, anhidrosis
Central lesions - anhidrosis of arm, trunk, face (4 Ss)
- Stroke
- MS
- Swelling (tumours)
- Syringomyelia
- also encephalitis
Pre-ganglionic lesions - anhidrosis of face (4 Ts)
- Tumour - eg Pancoast
- Trauma
- Thyroidectomy
- Top rib - cervical rib
Post-ganglionic lesions - no anhidrosis (4 Cs)
- Carotid aneurysm
- Carotid artery dissection
- Cavernous sinus thrombosis
- Cluster headache
Congenital Horner syndrome
- associated with heterochromia
Ix
- Cocaine eye drops? - cause dilatation in normal eye, not in Horner’s
- adrenaline eye drops - as above
Holmes Adie Pupil
- benign, part of Holmes-Adie syndrome - neuro disorder with absent ankle / knee reflexes
Px
- unilateral in 80%
- dilated pupil
- once pupil constricts, small for a while
- slow reaction to accommodation, barely any to light