T helper cell subsets Flashcards
What is the function of follicular helper T cells?
help B cells
What is expressed on Tfh cells?
CXCR5- chemokine receptor
Where are Tfh cells found?
in B cell follicles of secondary lymphoid organs
What cytokines do Tfh cells produce?
IL2; IL4; IL21 and IFNy
What is a special feature of Tfh cells?
antigen experienced- have already seen the antigen before from probably a DC
What is the function of IL-21 secreted by Tfh cells?
stimulate the formation of Tfh cells as well as B cells
What interaction is critical for CD4+ T cell help to cytotoxic T cells?
CD40:CD40L - between APC and Th or Th and CD8- probably both
What cytokines do Th1 cells produce?
IL-2 and IFNy
What cytokines do Th2 cells produce?
IL-4; IL-5; IL-10; IL-13
What do Th2 cells stimulate?
IgE; mast cells; eosinophils
What do Th1 cells stimulate?
IgG2a; macrophage activation; delayed hypersensitivity
What are Th cells which produce both type 1 and type 2 cytokines?
Th0 cells
What is polarisation?
development of Th1 or Th2 from a T-cell precursor
What cytokine drives the polarisation to Th1 /
IL12
What cytokine drives the polarisation to a Th2?
IL-4
