T-cells--Diebel

Question 1

Th1 differentiation cytokines

Answer 1

IL-12
IL-18
IFN-γ

Question 2

Th1 secreted cytokines

Answer 2

IFN-γ

TNF

Question 3

Th17 differentiation cytokines

Answer 3

IL-1
IL-6
IL-23
TGF-β

Question 4

Th17 secreted cytokines

Answer 4

IL-17

IL-22

Question 5

Th2 differentiation cytokines

Answer 5

IL-4

Question 6

Th2 secreted cytokines

Answer 6

IL-4
IL-5
IL-13

Question 7

Threg differentiation cytokines

Answer 7

IL-2

TGF-β

Question 8

Threg secreted cytokines

Answer 8

IL-10

TGF-β

Question 9

Thfh differentiation cytokines

Answer 9

IL-6

IL-21

Question 10

Thfh secreted cytokines

Answer 10

IL-4

IL-21

Question 11

Th1 transcription regulator

Answer 11

T-Bet

Question 12

Th17 transcription regulator

Answer 12

RORγt

Question 13

Th2 transcription regulator

Answer 13

GATA3

Question 14

Threg transcription regulator

Answer 14

FOXD3

Question 15

Thfh transcription regulator

Answer 15

Bcl-6

Question 16

α and β chains are interchangeable in the MHC-I/MHC-II molecule

Answer 16

MHC-II

Question 17

IFN-γ secreted by Th1 cells does what important action

Answer 17

M1 macrophage activation

Question 18

M1 macrophages secrete…

Answer 18

IL-1

TNF-α

Question 19

Th4 T-cells secrete IL-4, IL-5, and IL-13 that activate what type of cell

Answer 19

M2 macrophage

Question 20

Follicular cells secrete IL-4 and IL-21 that function to…

Answer 20

class switch B-cells

Question 21

Regulatory T-cells suppress the function of which cells?

Answer 21

activated CD4+ T-cells
Th0 cells (decreases proliferation)

Question 22

Cytotoxic T-cells depend on what activation mechanism?

Answer 22

FAS-FAS ligand in conjunction with CD8, TCR interacting with MHC-I

Question 23

T/F

Memory T-cells can redifferentiate back into cytotoxic T-cells

Answer 23

T

Question 24

How do you get memory T-cells from CD8+ cells?

Answer 24

medium expression of IL-2 receptor, like an ‘eh’ kind of differentiation

Question 25

Which type of cell express both MHC-I and MHC-II?

Answer 25

dendritic cells

Question 26

CD3 on T-cells is analogous to what on B-cells?

Answer 26

CD79a and CD79b

Question 27

T/F

Somatic hypermutation occurs in T-cells

Answer 27

F

T-cells are fully/terminally differentiated when they leave the thymus and don’t change after that

Question 28

TCR alpha genetics

Answer 28

VJ + constant region

Question 29

TCR beta genetics

Answer 29

VDJ + constant region

Question 30

T/F

Somatic mutation occurs in T-cells

Answer 30

T

somatic mutation: adding on some nucleotides to segments

Question 31

3 Class I gene loci

Answer 31

HLA-A
HLA-B
HLA-C

Question 32

of possible options for MHC-I α chain

Answer 32

6

HLA-A, B, and C from each mother and father

Question 33

3 Class II gene loci

Answer 33

HLA-DP
HLA-DQ
HLA-DR

Question 34

of possible options for MHC-II α and β combinations

Answer 34

12
HLA-DP, DQ, DR each from mother and father
alpha and beta from each
DPs MUST interact with other DPs, for example, however