Antineoplastic Principles--Fitz Flashcards
1
Q
The “kill hypothesis” depends on this principle you forgot from gen chem
A
first order kinetics
2
Q
This protein is encoded by the MDR (multidrug resistant) gene
A
P-glycoprotein
3
Q
What is the function of P-glycoprotein?
A
pumps out antineoplastics
4
Q
This type of drug is particularly good at causing multidrug resistant cancer lines
A
natural product drugs
5
Q
Continue cancer treatment until…
A
after cancer can be detected
6
Q
What is the principle of differential sensitivity?
A
affecting cancer cells more than normal cells because of some difference in process between the two
7
Q
CCS drugs depend on schedule/dosing more
A
schedule
8
Q
CCNS drugs depend on schedule/dosing more
A
dosing
