Immunology Review--Nelson

Question 1

Reactive follicular hyperplasia

Answer 1

B-cell response, gaining of germinal center in response to B-cell activation in lymph nodes

Question 2

CD20 markers are found on this cell type

Answer 2

B-cells

Question 3

CD3 markers are found on this cell type

Answer 3

T-cells

Question 4

Normal kappa:lambda ratio

Answer 4

1.5:1

Question 5

Bad kappa:lambda ratios

Answer 5

4

Question 6

Anaphylaxis causes severe hypertension/hypotension

Answer 6

hypotension

Question 7

What type of cell is synonymous with type I sensitivity?

Answer 7

mast cells

Question 8

What is the goal of exposure therapy on a molecular level?

Answer 8

trying to get IgG instead of IgE forming

Question 9

Pemphigous vulgaris is caused by…

Answer 9

antibody production against desmoglians 1 and 2

Question 10

Goodpasture syndrome pathology

Answer 10

autoantibodies against basement membrane material in kidneys

Question 11

Where do you get type III hypersensitivity the most?

Answer 11

places where fluid is filtered: kidneys, synovium

Question 12

What do you see on histological specimens in type III hypersensitivies? (*)

Answer 12

fibrinoid necrosis: dying of vessel

Question 13

Fibrinoid necrosis: what causes it?

Answer 13

complement binding to immune complexes (antigen + antibody complexes)

Question 14

What type of cell do you expect to see in type IV hypersensitivty reactions

Answer 14

CD4+ or CD8+ T-cells

Question 15

What are the three types of granulomas?

Answer 15

foreign body (stitches)
caseating (bad infections)
non-caseating (sarcoidosis, IBS)