Molecular Neoplasia Flashcards
What is the first mutation in a neoplasm?
driver mutation
What is a mutation that has no physiological consequences in a neoplasm?
passenger mutation
These are the two general types of cells that can transform to cause cancer
stromal or parenchymal
Her2/neu transformation
+ is some breast cancers
the you can use trastuzunab for treatment
KRAS mutation
+ in some colon cancers
limits Tx options because some not effective
BRCA 1/2 mutations
DNA mismatch repair
seen in some breast cancers
APC mutations
familial polyposis colon cancer
Bcl-2 mutation
follicular lymphoma
reduced cell death
prevents cytochrome c release
prevents caspace cascade
Makes new vessels and makes them leaky
VEGF
HNPCC: Hereditary Non-Polypoic Colon Cancer
inactivation of genes for DNA mismatch
autosomal dominant
Warburg effect and importance
aerobic glycolysis
more in cancer cells
PET scan takes advantage of this, increased radiolabelled glucose uptake
New classification focuses more on ________ and less on ________ and ________
- therapeutic targets
- morphology
- cell origin
