ALL-Krafts

Question 1

How are acute lymphoblastic leukemias classified?

Answer 1

immunophenotyping

B- vs. T-cells

Question 2

+ TdT indicates

Answer 2

ALL

Question 3

T-lymphoblastic leukemia/lymphoma typical patient

Answer 3

teenage male with mediastinal mass

*lots of T’s

Question 4

TdT + which cancers

Answer 4

acute myeloid leukemia

B-lymphobastic leukemia/lymphoma

Question 5

B-lymphoblastic leukemia population

Answer 5

children by far most common

Question 6

Prognostic features:

• Immunophenotype (T vs. B)
• Age
• WBC
• Cytogenetics

Answer 6

• T is bad
• 1-10 y/o is good
• <50,000 is good
• hyperdiploidy good

Question 7

Treatment of ALL

Answer 7

• chemo ± marrow transplant
• many children are cured