T cells Flashcards
T lymphocyte involved in effector function
cytotoxic T lymphocytes (Tc)
T lymphocyte involved in regulatory immune function
Helper T cells (Th cells)
How T cells react with antigen
T cell Receptor (TcR) - present on T cell membrane surface, derived from bone marrow
CD4+
- expressed by what cell
- interacts with which MHC
- binds with which region of MHC
- coreceptor on Th cells
- MHCII
- beta 2 domain of MHCII
CD3
- expressed by which cells
- important
both Tc and Th cells
important for clonal expansion
How B cells react with antigen
immunoglobulins
TcR look structurally similar to
FAB region on antibody where antigen binds
Two major types of CD4+
Th1, Th2
This specific type of cell modulates phagocytic cell and inflammatory reactions
Th1
This specific type of cell produce factors that help stimulate B cells to differentiate into plasma cells
Th2
TcR recognize what complex
MHCII with a bound processed peptidal antigen on an APC
Rearrangement of T cell receptors occur at this site
Thymus (arise in bone marrow, mature in thymus)
Which step of rearrangement/mode of diversity is NOT present in T cells?
Somatic hypermutation - only in B cells
TcR structure. Which part is equivalent to the heavy chain?
Valpha Vbeta
Calpha Cbeta
beta is like heavy chain
Which part of TcR structure will undergo rearrangement first?
Variable beta chain rearranges first, then produces alpha chain which will undergo VJ rearrangement like light chain
What is the signal that induces Th cell to become a Th1 cell?
IL-12 released from professional APC
Signature cytokine of Th1
interferon gama
After Th cell binds to profession APC, explain in 3 steps how it matures to Th1 cell
professional APC releases IL-12
induces Th to become Th1 cell
Th1 will release interferon gamma
Function of interferon gamma
professional APC (like macrophages) increase production of oxidative species = BETTER KILLER
Important property of interferon gamma
class switch factor. tells B cells to produce IgG for opsonization
When would you develop a Th1?
To produce IgG when macrophage wants to opsonize