T-Cell Immunity - Poholek Flashcards

You may prefer our related Brainscape-certified flashcards:
1
Q

Main Functions of CD4 T-helper cells

A

Secrete cytokines to direct other immune cells and recognize antigen presented by APCs in the context of MHC-II

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Main functions of CD8 Cytotoxic T-cells

A

Directly kill target cells and recognize antigen presented by APCs in the context of MHC-I

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Main target of Th1 cells

A

Targets intracellular microbes (mycobacteria, viruses, toxoplasma)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What does IFN-gamma do?

A

Drive macrophage activation, complement binding, increases MHC processing, and inhibit viral replication by upregulating defense genes.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What cytokine drives development of Th1 cells? What txn factor is the master regulator?

A

IL-12 and T-bet

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What do Th2 cells target?

A

Extracellular parasites

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Primary effector cytokines of Th2 cells

A

IL-4, IL-5, IL-13

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Master txn factor of Th2 cells

A

GATA3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Th2 mediated immunopathology

A
  1. Skin allergies
  2. Food allergies
  3. Seasonal Allergies

*IgE/Mast cell mediated

Allergic Asthma: Recruitment of eosinophils to the lungs and mucus secretion/restriction by IL-5

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Target of Th17 cells

A

Primarily fungus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Cytokines produced by Th17 cells

A

IL-17 and IL-22

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Th17 cell Differentiation

A

Inducible txn factor: STAT

Master Regulator: RORyt

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Th17 cell driven autoimmune diseases

A

Psoriasis

Most/all autoimmune diseases as well

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Where do TfH cells have their effector function?

A

In the germinal center

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Effector cytokine of Th1 cells

A

IFN-gamma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Inducing cytokine of Th1 cells

A

IL-12 and IFN-gamma

17
Q

Inducing transcription factor of Th1 cells

A

STAT1/4

18
Q

Inducing cytokine for Th2 cells

A

IL-4 and IL-33

19
Q

Inducing transcription factor for Th2 cells

A

STAT6