Patterns of Virus Infection - Kip Kinchington

Question 1

Acute Infections

Answer 1

Usually self-limiting, but can be deadly. Goal is to make lots of new virus quickly and spread.

Question 2

Persistent Infections

Answer 2

Starts with an acute primary infection. Virus genome finds a way to persist in the host and cause recurrent infections.

Question 3

R-selected replication

Answer 3

Associated with acute infections. “Higher quantity, lower quality”

Question 4

K-selected replication

Answer 4

Associated with latent infections. “Lower quantity, higher quality”

Question 5

Incubation Period

Answer 5

Time from exposure/infection to appearance of symptoms.

Question 6

Antigenic drift

Answer 6

Slow accumulation of mutations over time.

Question 7

Antigenic shift

Answer 7

Mixing of multiple genes as a result of recombination with another virus (influenza).

Question 8

Example of a chronic virus infection

Answer 8

Hepatitis B

Question 9

Example of a latent virus infection

Answer 9

Herpesvirus

Question 10

Example of a transforming infectin

Answer 10

Human Papilloma Virus

Question 11

Which animal model is commonly used for VZV?

Answer 11

SCID-Hu mice

Question 12

From which tissue does VZV replicate and shed during the primary acute infection?

Answer 12

Hair follicles

Question 13

Where does VZV reside during latency?

Answer 13

Neurons

Question 14

Virus discussed in class that blocks MHC-I presentation

Answer 14

HCMV

Question 15

Which viruses discussed promotes autophagy?

Answer 15

VZV and measles

Question 16

Role of VP16 in herpesvirus infections

Answer 16

Activation of immediate early genes

Question 17

What do EBV utilize for persistence?

Answer 17

B-cells

Question 18

Is LAT required for reactivation of herpes?

Answer 18

No.