Patterns of Viral Infection: Relation to Pathogenesis Flashcards
PI3K signaling leads to:
Actin remodeling, apoptosis, proliferation, autophagy, etc.
PI3K pathway and adenovirus
Adenovirus attaches to integrins and starts PI3K signaling. Subsequent actin remodeling leads to efficient entry.
PI3K pathway and influenza A
- Influenza A virus attachment causes clustering of lipid rafts and associated Rptk. Subsequent PI3K activation facilitates entry.
PI3K pathway and ebolavirus
Activation of PI3K-Akt is required for vesicular trafficking of virus particles, not entry.
HCMV and eIF4F
HCMV phosphorylates eIF4F in a PI3K and mTOR independent manner. Phosphorylation of 4E-BP is dependent on PI3K. This is also the case for vaccinia virus.
Viruses can act on all steps in the cell’s production of proteins from genes.
True
Viruses that inhibit transcription.
Poliovirus, alphavirus, and VSV
Which viral protein inhibits cellular txn by cleaving TBP?
Poliovirus, 3Cpro
Viruses mentioned that can inhibit polyadenylation of cellular pre-mRNAs
Influenza A and Enterovirus 71
Viruses mentioned that disrupt mRNA splicing machinery
HSV-1 and Ev71
Viruses mentioned that block mRNA trafficking from the nucleus to the cytoplasm.
Poliovirus, VSV, and adenovirus
NGS and microarrays yields direct information about the mechanisms responsible for changes in RNA levels
False
Viruses alter catabolic processes for ____ and anabolic processes for ____.
Generating energy, generating building blocks
Which virus protein is responsible for driving increased cellular glucose consumption
Adenovirus E4
How does HCMV affect glucose metabolism?
Increases glucose metabolism
