T cell Immunity

Question 1

Immature DC cells to active DC cells

Answer 1

Actived by danger signals and down regulate phago and micropin, gain ability to migrate and up regular CCR7
increase B7 and Cytokines

Question 2

Purpose of lymphnodes

Answer 2

centers of testing for DC cells to test T cells so dont need all over body

Question 3

what is Recirculation

Answer 3

Leave blood and stay in 2ndary for a day before migrating back

Question 4

T cell extravasation

Answer 4

Roling - L selection binds w/ addresssin cam on HEV cells
Activation - CCR7 and ligand activate chemokines that make integrin for next step
Adhesion - LFA-1 bind HEV to ICAm
Diapedesis - Migrates to lymphnode

Question 5

What is HEV

Answer 5

high end venules - vessels that flow into the lympnode and place where T cell extravasation occurs

Question 6

How do T cells leave the lymph if not matched

Answer 6

Medullary sinus and efferent lymphatic

Question 7

Clonal Expansion for T cells

Answer 7

Signal 1 (TCR binds to MHC- II) - CD3 (CD4 too short) Signals T cells and increases proteins for Anergy
Signal 2 (binds CD28(t) to B7(dc)) - Survial signal and stops Anergy unregulated CD40L
Signal 3 - DC cells direct differentiation into effector t Cells

Question 8

IL- 2R and IL-2

Answer 8

produced by sig 1 and 2 and ensures T cell prolife

Question 9

What is the importance in signal 2?

Answer 9

stop auto reactive T cells binding and preventing Perphieal tolerance

Question 10

What is the importance of CTLA-4

Answer 10

Blocks over clones by CD28 b7 binding comp ( important for autoimmune drug disease

Question 11

What signals get regulated when the T cell gets activated

Answer 11

Down S1P-R and increase CD69 ( decrease active t cells form leaving lymp)
Down L-selecting and CCR7 (signals that prevent effector T cells from leaving)
Increase VLA-4 and CXCL-8 ( allows e Tcells to leave)
Incrase CD44 and lFA-1 (helps to leave)

Question 12

What is the importance of anti VLA-4

Answer 12

stops e t cells from over extravasation

Question 13

Signal 3 TH17 targets

Answer 13

makes IL 6 & 17* (creates neutrophils)
for yeast and bacteria (EC)

Question 14

Signal 3 TH1 targets

Answer 14

makes IL-2 and IFN- gamma
for virus and vesicular bacteria

Question 15

IL- 6

Answer 15

TH17 and cause fevers

Question 16

IL-17

Answer 16

TH17 recruits neutrophils

Question 17

IL-2

Answer 17

Th1 activates CD8 cells

Question 18

IFN- gamma

Answer 18

TH1 and activates macrophages and inhibits TH2 diff

Question 19

Signal 3 TH2 targets

Answer 19

makes IL-4 & 5 and CD40L
for intestinal worms and allergies

Question 20

IL -5

Answer 20

TH2 and recruits eosinophils for worms

Question 21

Tfh

Answer 21

cytokines for B cells

Question 22

Tregs

Answer 22

Cytokine released when PPR isnt inflame or activated
inhibits t cell prolife and prevent autoimmune disease

Question 23

DC cells with TGF-beta and no PAMP or DAMP produce what?

Answer 23

Tregs bc TGF-Beta plus FOXP3 makes CD4 cells into TREGS

Question 24

FOXP3 + _____ = ?

Answer 24

TGF - beta with no stree = CD4 into tregs

Question 25

What happens to t cells after fight

Answer 25

some become Mem t cells and the rest get eaten up by phagocytosis

Question 26

Central M T cells

Answer 26

express CCR7 in lymph + blood
float in blood and prolife fast
but need clonal expansion = slow working

Question 27

Effector M T cells

Answer 27

Express CD45RO and constantly circulating
low prolife but immediate rxn

Question 28

What DC signal triggers TH17

Answer 28

IL-6 and TGF - Beta from Yeast and EC bacteria

Question 29

What DC signals trigger TH1

Answer 29

IL-12, IFN-Gamma from Virus and Vesicular bacteria

Question 30

What DC signals trigger TH2

Answer 30

IL-4 from worms and allergies

Question 31

What DC signals trigger TfH

Answer 31

IL-21 and binding to Binding to B cells

Question 32

Resident M T cells

Answer 32

in tissue
poor prolife but fast rxn