T and B cell Development Flashcards
Precursor stage (pre-B cell)
2nd step - Light chain recombinant V and J
Progenitor stage ( pro B cell)
1st step - Heavy chain recombinant V, D and J
Immature B cell
Negative selection (bind too tight to itself = death)
Only IgM
Naive B cell
leaves Bone marrow and does recirculation till activated, has IgM and IgD
what is RAG?
important eenzame in T and B cell recombination
Progenitor (pro T cell)
Recompose Beta chain ( VDJ )
Precursor T cell
recombinant Alpha chain (VJ)
Immature T cell
Goes through negative and positive selection,
DP T cells
Positive = just right binding MHC-I or MHC-II
Negative binding = too tight death
These occur in the Epithelia Thymus
SP T cells
testing occurs in Medullar Thymus and only undergoes negative binding
Naive T cell
Wait in thymus for DC cell to activate
What is need for SP to gain specificity
Macropahges and DC cells give rise to different peptides and need AIRE
Single Positive vs Double positive
single just has CD4 or CD8 double has both
What is AIRE roles?
to show T cells non-thymic peptides and without you have an autoimmune disease
What is SCID
t and b cells dont work b| finding - opportunistic infections
Lymphocyte deficiency
ADA, RAG, BTK, GAMA-chain, MCH-II, TAP, no thymus | BTK and Tap do not have said bc have T cells or B cells not both gone
what is ADA
Top of tree | brakes down DNA and needed for Scavenging pathway
What is Rag?
B and T cells |loss of recombinant
What is Gamma Chain deficiency
T and NK cells | needed for cytokine receptor signaling
what is MCH-II deficiency?
No positive selection for T cells
What is TAP deficiency
T cells | no MHC-I to CD8 cells
Findings - viral infections a lot
BTK
B cells| can’t get to pre to immature
Findings - encapsulated bacteria infections bc slippery
