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Immuno > Antigens > Flashcards

Antigens Flashcards

1
Q

Antibody Structure

A

4 Chains( 2 heavy and 2 light)

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2
Q

Variable region

A

Binds antigen and is on the top

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3
Q

constant region

A

binds Fc or complements

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4
Q

Fab Region

A

the whole top part of the antibody (both variable and constant)

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5
Q

Do light chain subclass effect function?

A

no they do not but have 2 subtypes kappa and lambda

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6
Q

Function of Antibodies?

A

Neutralization, opsonization, ADCC, Sensitizes, Complement

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7
Q

what is Neutralization

A

coats antigen to prevent dmg and inhibit its toxins

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8
Q

What is Opsonization?

A

Ig binds Fc to make it easier to eat

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9
Q

ADCC?

A

increased NK killing by IgG

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10
Q

Sensitization

A

IgE on mast cells

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11
Q

Complement system

A

IgG and IgM for classic pathway

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12
Q

How many antibodies do B cells have

A

Just one on each

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13
Q

Antibody protection on our RBC

A

they can’t bind to RBC, if you do see we run a DAT test and if positive for IgG you have a problem

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14
Q

What does a T cell look like?

A

TCR and CD3, Squares and Rods

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15
Q

What does the TCR resemble?

A

Antibody but only 2 chains and thus has lower affinity than antibodies

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16
Q

T cell anatomy

A

2 chain alpha and beta side with CD3 stalk

17
Q

what can bind contiguous and discontiguous peptides

A

T cells can only do contiguous but Antibodies can do both

18
Q

Polyclonal pros and cons

A

Can be made from animal or human and conventional a wide range of changes but is not specific and can cross react

19
Q

Monoclonal pros and cons

A

can be made from animal and is very specific but if antibodies change you are SOL and need a booster shot

20
Q

what is flow cytometry

A

shine a laser to trigger color to see which antibody is in the blood, T cells CD3, Helper and treg CD4, Killer CD8, B cells CD20, CD45 on hematopoietic, DR on antigen presenting cells (DC, MACRO and B cells)

21
Q

What is Depleting

A

Fab2 you have both top and bottom to deplete and neutralize

22
Q

What is non-Depleting

A

just have top so neutralize but can’t do depleting

Immuno (9 decks)

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