Antigen Presentation

Question 1

What is MHC - I

Answer 1

3 alpha bubbles and 1 beta2 foot to keep it standing (same in every person)
sees what is going on inside and bind peptides 8-11
Talks to CD8 and on all nucleated cells (not RBC)

Question 2

What is MHC - II

Answer 2

2 alpha and 2 beta butterfly
shows what is going on outside
Bind pep size 13-18
ONLY ON ANTIGEN PRESENTING CELLS ( DC, B, MACRO, Thymus epithelial
Talks to CD4

Question 3

how does MHC- I present?

Answer 3

Proteasome inside cells chops up pieces for TAP to grab
moves from ER to golgi to cell surface

Question 4

where is MHC-I made

Answer 4

Rough ER

Question 5

how does MHC-II present

Answer 5

endocytosis of external protein digested to get peptides
MHC-II binds then get exo to show On cell after INVARIANT CHAIN removed

Question 6

what is the role of the INVARIANT CHAIN

Answer 6

Blocks MHC-II to be filled with peptides imported from the TAP transporter

Question 7

what is HLA - DM

Answer 7

Guides and loads peptide on MHC-II, removes Invariant chain as well

Question 8

What are the ploygenics for MHC- I and II

Answer 8

MHC - I A, B and C | MHC-II DP, DQ and DR

Question 9

Polygenic subtypes that lead to diseases

Answer 9

T1D DR3 and 4 25% increase, MS DR2 4.8 increase, arthritis DR4 4.2% increase

Question 10

B27, 57, 35 good or bad for infection

Answer 10

B27 and 57 good B 35 bad

Question 11

Abacavir rxn with B57

Answer 11

can bind in site and create hypersensitive rxn within the pt ( common)

Question 12

What are Cross presenting DC and why is it important

Answer 12

some virus don’t affect DC so they need to be eaten up and these special cells then show them on MHC- I by spilling over