systemic disease Flashcards
what does mytonia mean
delayed muscle relaxation on stopping voluntary action
symptoms of classic dystrophia myotonica
AD mutation in dystrophia myotonica protein kinase gene DMPK
- muscle wasting and weakness
- mournful facial expression
- slurred speech
- frontal baldness in males
ocular myotonic dystrophy symptoms
- early-onset cataract
- ptosis
- hypermetropia
optic manifestations of neurofibromatosis type 1 (von Recklinghausen disease)
- optic glioma
- two or more lisch nodules
a patient has: peri-orbital swelling, prominent eyes, staring appearance of eyes and conjunctival injection
what would you do next
enquire about tremor
heat intolerance
examine thyroid and pulse
what are the signs of thyorid eye disease
- soft tissue involvement
- lid retraction
- proptosis
- optic neuropathy
- restrictive myopathy (inflammation and fibrosis)
treatment for thyroid eye disease
- control of thyroid dysfunction
- stop smoking
- systemic steroids
- radiotherapy
- monoclonal antibody treatment
- surgical decompression
dermatomyosis presentation in eyes
- heliotrope rash on eyelids
- dry eyes/scleritis
- bilateral eyelid discolouration
- swelling of the eyelids and peri orbital skin
ocular presentation of marfan’s syndrome
dislocated lens
what are some ocular manifestations of rheumatoid arthritis
- scleromalacia perforans
- peripheral ulcerative keratitis
what can cause posterior synechiae
- HLA B27
- idiopathic anterior uveitis
what can cause granulomatous anterior uveitis
- sarcoidosis
- TB
- syphilis
what infections can cause inflammatory eye disease
- TB
- herpetic
- CMV
- toxoplasmosis
- syphilis
- lyme disease
non-infective causes of inflammatory eye disease
- idiopathic syndromes
- HLA-B27
- juvenile arthritis
- sarcoidosis
- Behcets disease
what drugs can cause vortex keratopathy
- amiodarone
- hydroxychloroquine
- chlorpromazine
