systemic disease Flashcards

1
Q

what does mytonia mean

A

delayed muscle relaxation on stopping voluntary action

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2
Q

symptoms of classic dystrophia myotonica

A

AD mutation in dystrophia myotonica protein kinase gene DMPK

  • muscle wasting and weakness
  • mournful facial expression
  • slurred speech
  • frontal baldness in males
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3
Q

ocular myotonic dystrophy symptoms

A
  • early-onset cataract
  • ptosis
  • hypermetropia
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4
Q

optic manifestations of neurofibromatosis type 1 (von Recklinghausen disease)

A
  • optic glioma

- two or more lisch nodules

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5
Q

a patient has: peri-orbital swelling, prominent eyes, staring appearance of eyes and conjunctival injection

what would you do next

A

enquire about tremor
heat intolerance
examine thyroid and pulse

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6
Q

what are the signs of thyorid eye disease

A
  • soft tissue involvement
  • lid retraction
  • proptosis
  • optic neuropathy
  • restrictive myopathy (inflammation and fibrosis)
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7
Q

treatment for thyroid eye disease

A
  • control of thyroid dysfunction
  • stop smoking
  • systemic steroids
  • radiotherapy
  • monoclonal antibody treatment
  • surgical decompression
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8
Q

dermatomyosis presentation in eyes

A
  • heliotrope rash on eyelids
  • dry eyes/scleritis
  • bilateral eyelid discolouration
  • swelling of the eyelids and peri orbital skin
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9
Q

ocular presentation of marfan’s syndrome

A

dislocated lens

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10
Q

what are some ocular manifestations of rheumatoid arthritis

A
  • scleromalacia perforans

- peripheral ulcerative keratitis

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11
Q

what can cause posterior synechiae

A
  • HLA B27

- idiopathic anterior uveitis

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12
Q

what can cause granulomatous anterior uveitis

A
  • sarcoidosis
  • TB
  • syphilis
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13
Q

what infections can cause inflammatory eye disease

A
  • TB
  • herpetic
  • CMV
  • toxoplasmosis
  • syphilis
  • lyme disease
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14
Q

non-infective causes of inflammatory eye disease

A
  • idiopathic syndromes
  • HLA-B27
  • juvenile arthritis
  • sarcoidosis
  • Behcets disease
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15
Q

what drugs can cause vortex keratopathy

A
  • amiodarone
  • hydroxychloroquine
  • chlorpromazine
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16
Q

what drugs cause bulls eye maculopathy

A
  • hydroxychloroquine

- chloroquine

17
Q

what effects can steroid use have on the eyes

A

cause a rise in intra-ocular pressure