Systemic Connections

Question 1

what is a perception of microbes and our body

Answer 1

microbes are essential and we are adapted to each other- bacteria are not longer just pathogenic invaders

Question 2

the human microbe super organism

Answer 2

microbes are beneficial, provide resistance against pathogens, metabolic functions and immune activations. the bacteria host interacted is complex and diverse

Question 3

what is our goal with bacteria today

Answer 3

manage and preserve native microbres

Question 4

whats the new direction for therapies today

Answer 4

therapies to encourage healthy communities by using probiotics, prebiotics and targeted antimicrobials

Question 5

direct mechanisms for oral connections to systemic diseases is caused by what

Answer 5

translocation of oral bacteria and translocation of toxin produced by oral bacteria

Question 6

what is the mechanism for immune system mediated oral systemic connections

Answer 6

host hyper inflammatory phenotype common pathway to disease: IL1 gene polymorphisms associated with inc in period and systemic diseases

Question 7

what do epidemiologic studies show

Answer 7

association NOT Causation

Question 8

what is the pathogenesis of Infective Endocarditis

Answer 8

platelets and fibrin adhere to CT producing NBTE and bacteria from oral cavity bind to NBTE in blood stream. bacteria are then able to infiltrate heart, vascular tissue producing emboli and stroke

Question 9

IE microbiology

Answer 9

60% strep, AA, and gemella

25% skin bacteria of staph

Question 10

in practice does AP prevent bacteremia

Answer 10

NO. AP is not recommended except in high risk cases

Question 11

is there evidence dental procedures are associated with IE?

Answer 11

NO evidence

Question 12

what has been shown to reduce IE

Answer 12

Optimized regular oral hygiene measures to keep bacterial load low instead of giving AP

Question 13

high risk and high invasiveness of procedure is treated how?

Answer 13

single high dose of amoxicllin

Question 14

there is high evidence what prevents lung infection reducing nosocomial pneumonia

Answer 14

good oral hygeine prevent pneumonia

Question 15

casual relationship between preterm birth and oral bacteria?

Answer 15

no strong evidence oral bacteria causes pre term birth

Question 16

for patients with immunosuppression what should dentists do

Answer 16

no evidence for relationship of dental treatment or efficacy of ABs
Dentists should focus on maintaining good oral health but consider invasiveness of procedure and bacterial load and degree of immunosuprresion

Question 17

Periodontitis and diabetes

Answer 17

inc prevalence of perio in diabetics, treat period improve glycemic control. evidence is strong and effect is moderate

Question 18

Cardio Disease and oral bacteria

Answer 18

association between the two modest, a link has been established but causative link has NOT.
P gingivalis and other perio pathogens found in atherosclerotic lesions

Question 19

perio and pancreatic cancer

Answer 19

studies show inc risk of pancreatic cancer in pts w perio, maybe a common pathway

Question 20

oral biofilm and implanted devices

Answer 20

NO AP is recommended for any implanted device

Question 21

primary preventative strategy when treating puts with IE, pneumonia, Immunosuppression, and preterm birth

Answer 21

improve oral health and reduce bacterial load,

AP indicated only in HIGH risk situations

Question 22

Oral connections with Type 2 diabetes, Cardio disease and pancreatic cancer primary preventative strategy for dentists

Answer 22

treat perio disease to improve microbial profile, improve overall health by addressing risk factors such as smoking, stress

Question 23

Implanted device have not been connected to oral bacteria so what should dentist do

Answer 23

no special precautions needed work with primary MD

Question 24

How do we encourage healthy bacterial communities today

Answer 24

improve oral hygiene, encourage healthy diets, promote F, and repairs dentitions