Systemic Connections Flashcards
what is a perception of microbes and our body
microbes are essential and we are adapted to each other- bacteria are not longer just pathogenic invaders
the human microbe super organism
microbes are beneficial, provide resistance against pathogens, metabolic functions and immune activations. the bacteria host interacted is complex and diverse
what is our goal with bacteria today
manage and preserve native microbres
whats the new direction for therapies today
therapies to encourage healthy communities by using probiotics, prebiotics and targeted antimicrobials
direct mechanisms for oral connections to systemic diseases is caused by what
translocation of oral bacteria and translocation of toxin produced by oral bacteria
what is the mechanism for immune system mediated oral systemic connections
host hyper inflammatory phenotype common pathway to disease: IL1 gene polymorphisms associated with inc in period and systemic diseases
what do epidemiologic studies show
association NOT Causation
what is the pathogenesis of Infective Endocarditis
platelets and fibrin adhere to CT producing NBTE and bacteria from oral cavity bind to NBTE in blood stream. bacteria are then able to infiltrate heart, vascular tissue producing emboli and stroke
IE microbiology
60% strep, AA, and gemella
25% skin bacteria of staph
in practice does AP prevent bacteremia
NO. AP is not recommended except in high risk cases
is there evidence dental procedures are associated with IE?
NO evidence
what has been shown to reduce IE
Optimized regular oral hygiene measures to keep bacterial load low instead of giving AP
high risk and high invasiveness of procedure is treated how?
single high dose of amoxicllin
there is high evidence what prevents lung infection reducing nosocomial pneumonia
good oral hygeine prevent pneumonia
casual relationship between preterm birth and oral bacteria?
no strong evidence oral bacteria causes pre term birth
for patients with immunosuppression what should dentists do
no evidence for relationship of dental treatment or efficacy of ABs
Dentists should focus on maintaining good oral health but consider invasiveness of procedure and bacterial load and degree of immunosuprresion
Periodontitis and diabetes
inc prevalence of perio in diabetics, treat period improve glycemic control. evidence is strong and effect is moderate
Cardio Disease and oral bacteria
association between the two modest, a link has been established but causative link has NOT.
P gingivalis and other perio pathogens found in atherosclerotic lesions
perio and pancreatic cancer
studies show inc risk of pancreatic cancer in pts w perio, maybe a common pathway
oral biofilm and implanted devices
NO AP is recommended for any implanted device
primary preventative strategy when treating puts with IE, pneumonia, Immunosuppression, and preterm birth
improve oral health and reduce bacterial load,
AP indicated only in HIGH risk situations
Oral connections with Type 2 diabetes, Cardio disease and pancreatic cancer primary preventative strategy for dentists
treat perio disease to improve microbial profile, improve overall health by addressing risk factors such as smoking, stress
Implanted device have not been connected to oral bacteria so what should dentist do
no special precautions needed work with primary MD
How do we encourage healthy bacterial communities today
improve oral hygiene, encourage healthy diets, promote F, and repairs dentitions
