Synaptic Transmission Drugs

Question 1

metyrosine

Answer 1

• hypertension

- competitive inhibition of tyrosine hydroxylase

Question 2

reserpine

Answer 2

• hypertension

- inhibits VMT uptake of monoamines

Question 3

cocaine

Answer 3

• analgesia in surgery

- blocks monoamine reuptake

Question 4

amphetamine or ephedrine

Answer 4

• narcolepsy, ADHD

- reverse monoamine reuptake transporters

Question 5

naloxone, naltrexone

Answer 5

• opioid overdose or dependence

- non-peptide blockers of opioid receptors in CNS

Question 6

SSRIs

Answer 6

• depression/anxiety

- selective inhibition of serotonin reuptake transporter

Question 7

ACE inhibitors (ex lisinopril)

Answer 7

• hypertension

- inhibits peptide cleavage of Angiotensin I to Angiotensin II

Question 8

phenylephrine

Answer 8

-direct agonist of adrenergic receptor

Question 9

MAO inhibitor

Answer 9

• depression

- blockade of cytoplasmic metabolism of monoamines

Question 10

L-DOPA

Answer 10

• parkinson’s disease

- precursor of dopamine, stimulates dopamine production

Question 11

Carbidopa

Answer 11

• Parkinson’s disease
• Blocks L-DOPA conversion to dopamine. Doesn’t cross BBB so it protects peripheral adrenergic neurons from producing too much DA and NE

Question 12

Tyramine

Answer 12

• ingested in diet- not therapeutic

- competes with NE for transport in synaptic vesicle

Question 13

bretylium

Answer 13

• ventricular arrhythmia

- inhibit AP generation and calcium dependent synaptic vesicle fusion