Opioid Analgesics Flashcards
1
Q
Morphine
A
- u receptor
- Rx = severe pain
- SE = constipation, addiction, and tolerace
- antidote = naloxone
2
Q
moperidine
A
- K receptor
- Rx = severe pain
- SE = seizure, dysphoria, tremor, and respiratory depression
- also binds K+ channels, muscarinic receptors, and DA transporter
- Don’t use naloxone as antidote
3
Q
hydrocodone
A
- u and d receptors
- Rx = moderate pain and anti-coughing
- SE = constipation, respiratory depression, and nausea
- recreational drug
4
Q
codeine
A
- u receptor
- Rx= cough, diarrhea, irritable bowel syndrome, and narcolepsy
- SE = euphoria, itching, urinary retention, depression, and constipation
- active metabolite = morphine
5
Q
pentazocine
A
- antagonist for u receptor (-) and agonist for K (-) and d (+) receptors
- Rx = dental extraction
- SE = hallucinations and cardiovascular effects
- antagonizes the analgesic effects of morphine and meperidine
6
Q
naloxone
A
- antagonist for u, d, and K receptors
- Rx = antidote for opioid
- SE = change in mood, trembling, and change in heart rhythm
7
Q
methadone
A
- agonist for u and d
- SE = dependence
- used to treat dependence of opioid drugs (less likely to kill you and after a while it may help you quit
