Serotonin and Dopamine Drugs Flashcards
1
Q
5-HTP
A
- 5-HT precursor
- Rx = depression
2
Q
buspirone
A
- 5-HT1A partial agonist
- Rx= anxiety/depression
- side effects = early increase in anxiety
3
Q
sumatriptan
A
- 5-HT1D agonist
- Rx = migraine
- side effect= coronary vasoconstriction
4
Q
risperidone
A
- 5-HT2A/2C antagonist
- Rx = depression/psychosis
- side effect= weight gain/ akithesia
5
Q
ondansetron
A
- 5HT3
- Rx = chemo induced emisis
6
Q
fluoxetine
A
- SSRI
- Rx = Depression, OCD, anxiety, panic disorder, PTSD, and social phobia
- side effect= sexual dysfunction and insomnia
7
Q
sertraline
A
- SSRI
- Rx = Depression, OCD, anxiety, panic disorder, PTSD, and social phobia
- side effect= sexual dysfunction and insomnia
8
Q
L-DOPA
A
- DA precursor
- Rx = Parkinson’s
- side effect= arrhythmia and dyskinesia
9
Q
bromocriptine
A
- D2 agonist
- Rx = parkinson’s disease
10
Q
carbidopa
A
- aromatic acid decarboxylase inhibitor which is the enzyme that converst L-DOPA to DA. Carbidopa can’t cross the BBB so it just inhibits this rxn in the periphery (reduce DA production in the periphery when L-DOPA is given)
- Rx = Parkinson’s
- side effect= same as L-DOPA since incr DA
11
Q
selegiline
A
- MAO-B inhibitor
- Rx = Parkinson’s
- side effects= hypotension or hypertensive crisis
- contraindication with sympathomimetics
12
Q
Tolcapone
A
- COMT inhibitor
- Rx= Parkinson’s
- contraindication= liver failure
13
Q
Methylphenidate
A
- DA reuptake inhibitor
- Rx = ADHD
- side effect= tachycardia
14
Q
metaclopramide
A
- D2 antagonist
- Rx = nausea
- side effect= akathisia
15
Q
haloperidol
A
- D2 antagonist
- Rx = psychosis
- -side effect= extra-pyrmaidal motor disturbances
