Neuromuscular Relaxant Drugs Flashcards
1
Q
Pancuronium
A
- Duration 30-60 min
- non-depol blockade of muscle nicotinic receptors
- E by primarily renal excretion
- Rx = adjuvant in surgical anesthesia, abdominal wall relaxant and orthopedic procedures
2
Q
D-tubocurarine
A
- Duration > 60 min
- non-depol blockade of muscle nicotinic receptors
- liver clearance and renal elimination
- Rx = prototype only
3
Q
rocuronium
A
- Duration = 25 min
- non-depol blockade of muscle nicotinic receptors
- E by Liver
- Rx= intubation, muscle relaxation during surgery or ventilation
4
Q
mivacrurium
A
- Duration = 15-20 min
- non-depol blockade of muscle nicotinic receptors
- E by plasma cholinesterase
- Rx = intubation, muscle relaxation during surgery or ventilation in pts with renal failure
5
Q
vecuronium
A
- Duration30-45 min
- non-depol blockade of muscle nicotinic receptors
- E by Liver metabolism and clearance, renal elimination
- Rx = adjuvant in surgical anesthesia, abdominal wall relaxant and orthopedic procedures
6
Q
baclofen
A
- inhibits nt release from skeletal muscle sensory afferent
- muscle spasticity assoc with multiple sclerosis or spinal cord injury
7
Q
diazepam
A
- benzodiazepine receptor agonist
- muscle spasm due to local injury (inflammation), muscle spastiscity due to loss of descending inhibitory input (cerebral palsy)
8
Q
tizanidine
A
- centrally acting a2 agonist
- muscle spasticity assoc with multiple sclerosis or spinal cord injury
9
Q
dantrolene
A
- uncouples excitation-contraction of skeletal muscle (blocks ryanodine recepto)
- muscle spasm, malignant hyperthermia
10
Q
Side effects of neuromuscular drugs
A
Non analgesic, apnea (must be ventilated)
11
Q
Succinylcholine
A
- duration is less than 8 min
- depol blockade of muscle nicotinic receptors
- metab by plasma cholinesterase
- Rx = tracheal intubation or ECT
