Sympathomiometics onset/peak/duration/receptor site stimulation Flashcards
Ephedrine dose?
2.5-10 mg
Ephedrine onset?
Less than 1 min
Ephedrine peak?
2-5 minutes
Ephedrine duration?
10-60 minutes
Ephedrine is alpha 1, alpha 2, beta 1, beta 2 agonist?
primarily indirect alpha 1 and beta 1
small amount of direct agonism as well
Phenylephrine dose?
40-100 mcg
Phenylephrine onset?
Less than 1 minute
Phenylephrine peak?
1 minute
Phenylephrine duration?
15-30 minutes
Phenylephrine is an alpha 1, alpha 2, beta 1, beta 2 agonist?
Alpha 1
Epinephrine dose?
2-20 mcg/min
Epinephrine onset?
30 seconds
Epinephrine peak?
3 minutes
Epinephrine duration?
10 minutes
Alpha 1 stimulation causes?
Increase inotrophy and vasoconstriction
Alpha 2 stimulation causes?
Vasodilation due to CNS presynaptic inhibition of norepinephrine
Beta 1 stimulation causes?
Increase inotrophy, chronotrophy, and dromptrophy
Beta 2 stimulation causes?
Increase inotrophy, chronotrophy, vascular dilation, and bronchial dilation
DA1 stimulation causes?
Vasodilation
DA2 stimulation causes?
Inhibition of norepinephrine release
Epinephrine stimulation causes alpha 1, alpha 2, beta 1, beta 2 agonist?
All of the above
Epinephrine Metabolism?
Monoamine Oxidase
Phenylephrine Metabolism?
Monoamine Oxidase
Ephedrine Metabolism?
Hepatic with Renal Elimination
Ephedrine max dose?
50 mg