Opoid Drug Dose/Onset/Duration

Question 1

Fentanyl induction dose?

Answer 1

2-20 mcg/kg induction as adjunct to Volatile Anesthetic

50-150 mcg/kg induction alone for cardiac surgery

Question 2

Fentanyl onset?

Answer 2

30 seconds

Question 3

Fentanyl peak?

Answer 3

5-15 minutes

Question 4

Fentanyl duration?

Answer 4

30-60 minutes

Question 9

Morphine induction dose?

Answer 9

0.1-1 mg/kg

Question 10

Morphine onset?

Answer 10

5 - 10 minutes

Question 11

Morphine peak?

Answer 11

15 minutes

Question 12

Morphine duration?

Answer 12

2 - 4 hours

Question 13

Meperidine dose?

Answer 13

0.5-2 mg/kg

Question 14

Meperidine onset?

Answer 14

30 seconds - 1 minute

Question 15

Meperidine peak?

Answer 15

5-15 minutes

Question 16

Meperidine duration?

Answer 16

2-4 hours

Question 17

Dilaudid dose

Answer 17

0.01 - 0.04 mg/kg or 0.5 -2 mg

Question 18

Dilaudid onset

Answer 18

10 - 15 minutes

Question 19

Dilaudid peak

Answer 19

20 - 30 minutes

Question 20

Dilaudid duration

Answer 20

2 - 3 hours

Question 21

Ketorlac IV dose?

Answer 21

30 mg

Question 22

Ketorlac onset?

Answer 22

10 minutes

Question 23

Ketorlac peak

Answer 23

1-2 hours

Question 24

Ketorlac duration?

Answer 24

6 hours

Question 25

Sufentanil induction dose?

Answer 25

0.6 - 4 mcg/kg

Question 26

Sufentanil onset?

Answer 26

1-3 minutes

Question 27

Sufentanil peak?

Answer 27

3-5 minutes

Question 28

Sufentanil duration?

Answer 28

20-45 minutes

Question 29

Alfentanil induction dose?

Answer 29

8-100 mcg/kg induction dose

0.5-3 mcg/kg/min infusion dose

Question 30

Alfentanil onset?

Answer 30

1-2 minutes

Question 31

Alfentanil duration?

Answer 31

10-15 minutes

Question 32

Alfentanil peak?

Answer 32

1-2 minutes

Question 33

Fentanyl MOA?

Answer 33

Mu opioid receptor Agonist - Inhibits Adenyl Cyclase causing a decrease in Ca influx into the cytoplasm inhibiting the presynaptic Ca channels from opening and preventing release of the neurotransmitter.

Question 34

Alfentanil MOA?

Answer 34

Mu opioid receptor Agonist - Inhibits Adenyl Cyclase causing a decrease in Ca influx into the cytoplasm inhibiting the presynaptic Ca channels from opening and preventing release of the neurotransmitter.

Question 35

Sufentanil MOA?

Answer 35

Mu opioid receptor Agonist - Inhibits Adenyl Cyclase causing a decrease in Ca influx into the cytoplasm inhibiting the presynaptic Ca channels from opening and preventing release of the neurotransmitter.

Question 36

Morphine MOA?

Answer 36

Mu opioid receptor Agonist - Inhibits Adenyl Cyclase causing a decrease in Ca influx into the cytoplasm inhibiting the presynaptic Ca channels from opening and preventing release of the neurotransmitter.

Question 37

Ketorlac MOA?

Answer 37

Inhibiting cyclooxygenase preventing synthesis of prostaglandins

Question 38

Naloxone dose?

Answer 38

0.4-2 mg ( Titrate to effect)

Question 39

Naloxone Onset?

Answer 39

1-2 minutes

Question 40

Naloxone Peak?

Answer 40

5-15 minutes

Question 41

Naloxone Duration?

Answer 41

1-2 hours

Question 42

Naloxone MOA?

Answer 42

Nonselective opoid antagonist - Effectively displaces the opioid from the Mu receptor

Question 43

Sufentanil Metabolism?

Answer 43

Hepatic and Small Intestine

Question 44

Alfentanil Metabolism?

Answer 44

Hepatic with Renal excreation

Question 45

Fentanyl Metabolism?

Answer 45

Hepatic with Pulmonary and renal elimination

Question 45

Morphine Metabolism?

Answer 45

Hepatic phase 1 conjugation

Question 45

Ketorlac Metabolism?

Answer 45

Hepatic

Question 45

Naloxone Metabolism?

Answer 45

Hepatic with Renal elimination