Anti-inflammatory and Immunosuppressants (steroids) Flashcards
2
Q
Dexamethasone dose
A
4 mg
2
Q
Dexamethasone onset
A
~ 1 hour
3
Q
Dexamethasone duration
A
> 24 hours
4
Q
Dexamethasone MOA
A
immunosuppressant and anti-inflammatory
produces glucocorticoid effects
5
Q
Dexamethasone metabolism
A
hepatic metabolism
renal elimination
6
Q
Hydrocortisone dose
A
25 - 150 mg
7
Q
Hydrocortisone duration
A
8 - 12 hours
8
Q
Hydrocortisone MOA
A
immunosuppressant and anti-inflammatory
produces glucocorticoid and mineralocorticoid effects
9
Q
Hydrocortisone metabolism
A
hepatic metabolism
renal elimination
10
Q
Which is more potent: hydrocortisone or dexamethasone?
A
dexamethasone is 25 times more potent than hydrocortisone
11
Q
What effect is seen with a glucocorticoid? or with a mineralocorticoid?
A
glucocorticoid effect - anti-inflammatory
mineralocorticoid effect - renal sodium retention
