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Top Shelf (bare-bones) > Neuromuscular Blocker Drug Onset/Dose/Duration > Flashcards

Neuromuscular Blocker Drug Onset/Dose/Duration Flashcards

1
Q

Succinylcholine Dose?

A

1-1.5 mg/kg

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2
Q

Succinylcholine Onset?

A

30 seconds - 1 minute

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3
Q

Succinylcholine Peak?

A

1 minute

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4
Q

Succinylcholine Duration?

A

5-10 minutes

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5
Q

Succinylcholine MOA?

A

Nicotinic Acetylcholine Receptor Antagonist - Binds to both alpha subunits on the Nicotinic Acetylcholine receptor on the Na channel displacing achetylcholine causing a depolarization.

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6
Q

Succinylcholine Metabolized by?

A

Plasma Pseudocholinesterase

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7
Q

Succinylcholine Side Effects?

A

Increase HR / Inotropy, fasiculations, Myalgias, Large Potassium release.

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8
Q

Rocuronium Dose?

A

0.6 -1.2 mg/kg

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9
Q

Rocuronium Onset?

A

1 minute 30 Seconds

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10
Q

Rocuronium Peak?

A

1-2 minutes

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11
Q

Rocuronium Duration?

A

20 - 35 minutes

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12
Q

Rocuronium MOA?

A

Nicotinic Acetylcholine Receptor Antagonist - Binds to ONE of the alpha subunits of the Nicotinic Acetylcholine receptor on the Na Channel preventing depolarization.

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13
Q

Rocuronium RSI Dose and Onset?

A

1.5 mg/kg, 1 minute

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14
Q

Vecuronium Dose?

A

0.08 - 0.1 mg/kg

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15
Q

Vecuronium Onset?

A

2 minutes

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16
Q

Vecuronium Peak?

A

2-3 minutes

17
Q

Vecuronium Duration?

A

20-35 minutes

18
Q

Vecuronium MOA?

A

Nicotinic Acetylcholine Receptor Antagonist - Binds to ONE of the alpha subunits of the Nicotinic Acetylcholine receptor on the Na Channel preventing depolarization.

19
Q

Pancuronium Dose?

A

0.08-0.1 mg/kg

20
Q

Pancuronium Onset?

A

1-3 minutes

21
Q

Pancuronium Peak?

A

3-5 minutes

22
Q

Pancuronium Duration?

A

60 -90 minutes

23
Q

Pancuronium MOA?

A

Nicotinic Acetylcholine Receptor Antagonist - Binds to ONE of the alpha subunits of the Nicotinic Acetylcholine receptor on the Na Channel preventing depolarization.

24
Q

Pancuronium Side Effects?

A

Increase HR due to Vagolysis at the postganglionic nerve synaps, Inhibits Plasmacholinesterase.

25
Q

Cisatracurium Dose?

A

0.15-0.2 mg/kg

26
Q

Cisatracurium Onset?

A

1 minute 30 seconds

27
Q

Cisatracurium Duration?

A

20-35 minutes

28
Q

Cisatracurium MOA?

A

Nicotinic Acetylcholine Receptor Antagonist - Binds to ONE of the alpha subunits of the Nicotinic Acetylcholine receptor on the Na Channel preventing depolarization.

29
Q

Cisatracurium Metabolism?

A

Hoffman and Ester Hydrolysis

30
Q

Cisatracurium Specific concerns?

A

Needs to be Refrigerated, Increase pH will increase metabolism

31
Q

Rocuronium Metabolism?

A

Hepatic and Renal with Biliary excretion

32
Q

Vecuronium Metabolism?

A

Hepatic and Renal with Biliary excretion

33
Q

Pancuronium Metabolism?

A

Renal

Top Shelf (bare-bones) (12 decks)

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