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Top Shelf (bare-bones) > Neuromuscular Blocker Drug Onset/Dose/Duration > Flashcards

Neuromuscular Blocker Drug Onset/Dose/Duration Flashcards

1
Q

Succinylcholine Dose?

A

1-1.5 mg/kg

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2
Q

Succinylcholine Onset?

A

30 seconds - 1 minute

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3
Q

Succinylcholine Peak?

A

1 minute

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4
Q

Succinylcholine Duration?

A

5-10 minutes

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5
Q

Succinylcholine MOA?

A

Nicotinic Acetylcholine Receptor Antagonist - Binds to both alpha subunits on the Nicotinic Acetylcholine receptor on the Na channel displacing achetylcholine causing a depolarization.

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6
Q

Succinylcholine Metabolized by?

A

Plasma Pseudocholinesterase

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7
Q

Succinylcholine Side Effects?

A

Increase HR / Inotropy, fasiculations, Myalgias, Large Potassium release.

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8
Q

Rocuronium Dose?

A

0.6 -1.2 mg/kg

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9
Q

Rocuronium Onset?

A

1 minute 30 Seconds

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10
Q

Rocuronium Peak?

A

1-2 minutes

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11
Q

Rocuronium Duration?

A

20 - 35 minutes

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12
Q

Rocuronium MOA?

A

Nicotinic Acetylcholine Receptor Antagonist - Binds to ONE of the alpha subunits of the Nicotinic Acetylcholine receptor on the Na Channel preventing depolarization.

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13
Q

Rocuronium RSI Dose and Onset?

A

1.5 mg/kg, 1 minute

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14
Q

Vecuronium Dose?

A

0.08 - 0.1 mg/kg

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15
Q

Vecuronium Onset?

A

2 minutes

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16
Q

Vecuronium Peak?

A

2-3 minutes

17
Q

Vecuronium Duration?

A

20-35 minutes

18
Q

Vecuronium MOA?

A

Nicotinic Acetylcholine Receptor Antagonist - Binds to ONE of the alpha subunits of the Nicotinic Acetylcholine receptor on the Na Channel preventing depolarization.

19
Q

Pancuronium Dose?

A

0.08-0.1 mg/kg

20
Q

Pancuronium Onset?

A

1-3 minutes

21
Q

Pancuronium Peak?

A

3-5 minutes

22
Q

Pancuronium Duration?

A

60 -90 minutes

23
Q

Pancuronium MOA?

A

Nicotinic Acetylcholine Receptor Antagonist - Binds to ONE of the alpha subunits of the Nicotinic Acetylcholine receptor on the Na Channel preventing depolarization.

24
Q

Pancuronium Side Effects?

A

Increase HR due to Vagolysis at the postganglionic nerve synaps, Inhibits Plasmacholinesterase.

25
Cisatracurium Dose?
0.15-0.2 mg/kg
26
Cisatracurium Onset?
1 minute 30 seconds
27
Cisatracurium Duration?
20-35 minutes
28
Cisatracurium MOA?
Nicotinic Acetylcholine Receptor Antagonist - Binds to ONE of the alpha subunits of the Nicotinic Acetylcholine receptor on the Na Channel preventing depolarization.
29
Cisatracurium Metabolism?
Hoffman and Ester Hydrolysis
30
Cisatracurium Specific concerns?
Needs to be Refrigerated, Increase pH will increase metabolism
31
Rocuronium Metabolism?
Hepatic and Renal with Biliary excretion
32
Vecuronium Metabolism?
Hepatic and Renal with Biliary excretion
33
Pancuronium Metabolism?
Renal

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