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Top Shelf (bare-bones) > GI protectants / Antiemetics > Flashcards

GI protectants / Antiemetics Flashcards

1
Q

Ondansetron dose

A

4 mg

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2
Q

Ondansetron onset

A

~ 30 minutes

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3
Q

Ondansetron peak

A

2 hours

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4
Q

Ondansetron duration

A

4 - 24 hours

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5
Q

Ondansetron MOA

A

5-HT3 receptor antagonist or serotonin antagonist

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6
Q

Ondansetron metabolism

A

hepatic metabolism

renal elimination

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7
Q

When is ondansetron contraindicated?

A

with decreased GI motility or decreased lower esophageal sphincter tone

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8
Q

Droperidol dose

A

0.625 - 2.5 mg

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9
Q

Droperidol onset

A

1 - 2 minutes

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10
Q

Droperidol peak

A

30 minutes

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11
Q

Droperidol duration

A

2 - 4 hours

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12
Q

Droperidol MOA

A

dopamine-2 (D2) receptor antagonist

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13
Q

Well known cardiac effect of droperidol

A

can prolong QT interval

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14
Q

Droperidol metabolism

A

hepatic metabolism

renal elimination

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15
Q

Diphenhydramine dose

A

50 mg

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16
Q

Diphenhydramine duration

A

3 - 6 hours

17
Q

Diphenhydramine MOA

A

H1 antagonist

selectively antagonizes H1 receptors, blocking histamine activation of gastric parietal cell proton pump

18
Q

Ranitidine dose

A

2 - 4 mg/kg

19
Q

Ranitidine peak

A

1 - 3 hours

20
Q

Ranitidine duration

A

1.5 - 2.5 hours

21
Q

Ranitidine MOA

A

H2 antagonist

selectively antagonizes H2 receptors, blocking histamine activation of gastric parietal cell proton pump

22
Q

Should the ranitidine dose be increased or decreased with advancing age and/or renal dysfunction?

A

decrease the dose

23
Q

Ranitidine metabolism

A

hepatic metabolism

renal elimination

24
Q

Diphenhydramine metabolism

A

hepatic metabolism

renal elimination

25
Q

Omeprazole dose

26
Q

Omeprazole onset

A

2 - 4 hours

27
Q

Omeprazole peak

A

2 - 4 hours

28
Q

Omeprazole duration

A

> 24 hours

29
Q

Omeprazole MOA

A

proton pump inhibitor

directly inhibits the H+/K+ ATP-ase proton pump, leading to an increase in gastric pH and a decrease in fluid volume

30
Q

Omeprazole metabolism

A

hepatic metabolism

renal elimination

31
Q

Metoclopramide dose

A

10 - 20 mg

32
Q

Metoclopramide onset

A

1 - 2 minutes

33
Q

Metoclopramide peak

34
Q

Metoclopramide duration

A

1 - 2 hours

35
Q

Metoclopramide MOA

A

GI prokinetic and dopamine-2 (D2) receptor antagonist

[produces selective cholinergic stimulation of GI tract by:

1) increasing SM tone in lower esophageal sphincter and stomach
2) increasing gastric and small intestine motility
3) relaxes pylorus and duodenum when stomach contracts]

36
Q

Metoclopramide metabolism

A

hepatic metabolism

renal elimination

Top Shelf (bare-bones) (12 decks)

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