GI protectants / Antiemetics

Question 1

Ondansetron dose

Answer 1

4 mg

Question 2

Ondansetron onset

Answer 2

~ 30 minutes

Question 3

Ondansetron peak

Answer 3

2 hours

Question 4

Ondansetron duration

Answer 4

4 - 24 hours

Question 5

Ondansetron MOA

Answer 5

5-HT3 receptor antagonist or serotonin antagonist

Question 6

Ondansetron metabolism

Answer 6

hepatic metabolism

renal elimination

Question 7

When is ondansetron contraindicated?

Answer 7

with decreased GI motility or decreased lower esophageal sphincter tone

Question 8

Droperidol dose

Answer 8

0.625 - 2.5 mg

Question 9

Droperidol onset

Answer 9

1 - 2 minutes

Question 10

Droperidol peak

Answer 10

30 minutes

Question 11

Droperidol duration

Answer 11

2 - 4 hours

Question 12

Droperidol MOA

Answer 12

dopamine-2 (D2) receptor antagonist

Question 13

Well known cardiac effect of droperidol

Answer 13

can prolong QT interval

Question 14

Droperidol metabolism

Answer 14

hepatic metabolism

renal elimination

Question 15

Diphenhydramine dose

Answer 15

50 mg

Question 16

Diphenhydramine duration

Answer 16

3 - 6 hours

Question 17

Diphenhydramine MOA

Answer 17

H1 antagonist

selectively antagonizes H1 receptors, blocking histamine activation of gastric parietal cell proton pump

Question 18

Ranitidine dose

Answer 18

2 - 4 mg/kg

Question 19

Ranitidine peak

Answer 19

1 - 3 hours

Question 20

Ranitidine duration

Answer 20

1.5 - 2.5 hours

Question 21

Ranitidine MOA

Answer 21

H2 antagonist

selectively antagonizes H2 receptors, blocking histamine activation of gastric parietal cell proton pump

Question 22

Should the ranitidine dose be increased or decreased with advancing age and/or renal dysfunction?

Answer 22

decrease the dose

Question 23

Ranitidine metabolism

Answer 23

hepatic metabolism

renal elimination

Question 24

Diphenhydramine metabolism

Answer 24

hepatic metabolism

renal elimination

Question 25

Omeprazole dose

Answer 25

20 mg PO

Question 26

Omeprazole onset

Answer 26

2 - 4 hours

Question 27

Omeprazole peak

Answer 27

2 - 4 hours

Question 28

Omeprazole duration

Answer 28

> 24 hours

Question 29

Omeprazole MOA

Answer 29

proton pump inhibitor | directly inhibits the H+/K+ ATP-ase proton pump, leading to an increase in gastric pH and a decrease in fluid volume

Question 30

Omeprazole metabolism

Answer 30

hepatic metabolism renal elimination

Question 31

Metoclopramide dose

Answer 31

10 - 20 mg

Question 32

Metoclopramide onset

Answer 32

1 - 2 minutes

Question 33

Metoclopramide peak

Answer 33

5 minutes

Question 34

Metoclopramide duration

Answer 34

1 - 2 hours

Question 35

Metoclopramide MOA

Answer 35

GI prokinetic and dopamine-2 (D2) receptor antagonist [produces selective cholinergic stimulation of GI tract by: 1) increasing SM tone in lower esophageal sphincter and stomach 2) increasing gastric and small intestine motility 3) relaxes pylorus and duodenum when stomach contracts]

Question 36

Metoclopramide metabolism

Answer 36

hepatic metabolism renal elimination