Neuromuscular Blocker Reversal Drug Onset/Dose/Duration

Question 1

Glycopyrolate Class?

Answer 1

Anticholinergic

Question 2

Glycopyrolate Dose?

Answer 2

0.2 mg per 1 mg of Neostigmine

Question 3

Glycopyrolate Onset?

Answer 3

4 minutes

Question 4

Glycopyrolate Peak?

Answer 4

5 minutes

Question 5

Glycopyrolate Duration?

Answer 5

2-7 hours

Question 6

Glycopyrolate MOA?

Answer 6

Muscarinic Receptor Antagonist - Competitively displaces acetylcholine at the Muscarinic Acetylcholine receptor, preventing parasympathetic stimulation. Does not cross the blood brain barrier.

Question 7

Glycopyrolate Side effects?

Answer 7

Bronchodilation, decrease secretions, decrease motion induced nausea

Question 8

Neostigmine class?

Answer 8

Anticholiesterase

Question 9

Neostigmine Dose?

Answer 9

0.04 - 0.08 mg/kg MAX=> 5 mg

Question 10

Neostigmine Onset?

Answer 10

5-10 minutes

Question 11

Neostigmine Peak?

Answer 11

10 minutes

Question 12

Neostigmine Duration?

Answer 12

1 hour

Question 13

Neostigmine MOA?

Answer 13

Covalently bonds to Acetycholinesterase causing permanent Deactivation allowing Acetycholine to increase in the synapse

Question 14

Neostigmine Side Effects?

Answer 14

Bronchoconstriction, Decrease HR/BP/CO/IOP, increases nausea and secreations.

Question 15

Atropine Class?

Answer 15

Anticholinergic / Parasympatholytic

Question 16

Atropine Dose?

Answer 16

0.01 mg/kg

Question 17

Atropine Onset?

Answer 17

1 minute

Question 18

Atropine Peak?

Answer 18

2 minute

Question 19

Atropine Duration?

Answer 19

1-4 hours

Question 20

Atropine MOA?

Answer 20

Muscarinic Receptor Antagonist - Competitively displaces acetylcholine at the Muscarinic Acetylcholine receptor, preventing parasympathetic stimulation.

Question 21

Atropine Side Effects?

Answer 21

Increase in HR R/T vagal inhibition of the SA and AV conduction

Question 22

Edrophonium Class?

Answer 22

Anticholinesterase

Question 23

Edrophonium Dose?

Answer 23

0.5-1 mg/kg MAX 40 mg

Question 24

Edrophonium Onset?

Answer 24

30 seconds to 1 minute

Question 25

Edrophonium Peak?

Answer 25

1 minute

Question 26

Edrophonium Duration?

Answer 26

45 minutes

Question 27

Edrophonium MOA?

Answer 27

Cholinesterase Inhibitor - Binds REVERSIBLY to the negative charge on Acetylcholinesterase preventing Acetylcholine breakdown.

Question 28

Edrophonium Side Effects?

Answer 28

Bronchoconstriction, Decrease in HR/BP/CO/IOP, increases secretions and nausea, NOT recommended for a deep block.

Question 29

Edrophonium Metabolism?

Answer 29

75% Renal and 25% Hepatic

Question 30

Scopalomine Class?

Answer 30

Anticholinergic

Question 31

Scopalomine Dose?

Answer 31

0.2-1 mg (usually IM)

Question 32

Scopalomine Onset?

Answer 32

5-10 Minutes

Question 33

Scopalomine Peak?

Answer 33

20-60 minutes

Question 34

Scopalomine Duration?

Answer 34

2 hours

Question 35

Scopalomine MOA?

Answer 35

Muscarinic Receptor Antagonist - Competitively displaces acetylcholine at the Muscarinic Acetylcholine receptor, preventing parasympathetic stimulation.

Question 36

Scopalomine Side Effects?

Answer 36

Bronchodilation, Increase in CO, decrease motion sickness nausea, decreases secretions, amnesia and sedation

Question 37

Scopalomine Metabolism?

Answer 37

Hepatic with Renal excreation

Question 38

Neostigmine Metabolism?

Answer 38

50% Hepatic and 50 % Renal