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Top Shelf (bare-bones) > Neuromuscular Blocker Reversal Drug Onset/Dose/Duration > Flashcards

Neuromuscular Blocker Reversal Drug Onset/Dose/Duration Flashcards

1
Q

Glycopyrolate Class?

A

Anticholinergic

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2
Q

Glycopyrolate Dose?

A

0.2 mg per 1 mg of Neostigmine

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3
Q

Glycopyrolate Onset?

A

4 minutes

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4
Q

Glycopyrolate Peak?

A

5 minutes

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5
Q

Glycopyrolate Duration?

A

2-7 hours

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6
Q

Glycopyrolate MOA?

A

Muscarinic Receptor Antagonist - Competitively displaces acetylcholine at the Muscarinic Acetylcholine receptor, preventing parasympathetic stimulation. Does not cross the blood brain barrier.

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7
Q

Glycopyrolate Side effects?

A

Bronchodilation, decrease secretions, decrease motion induced nausea

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8
Q

Neostigmine class?

A

Anticholiesterase

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9
Q

Neostigmine Dose?

A

0.04 - 0.08 mg/kg MAX=> 5 mg

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10
Q

Neostigmine Onset?

A

5-10 minutes

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11
Q

Neostigmine Peak?

A

10 minutes

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12
Q

Neostigmine Duration?

A

1 hour

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13
Q

Neostigmine MOA?

A

Covalently bonds to Acetycholinesterase causing permanent Deactivation allowing Acetycholine to increase in the synapse

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14
Q

Neostigmine Side Effects?

A

Bronchoconstriction, Decrease HR/BP/CO/IOP, increases nausea and secreations.

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15
Q

Atropine Class?

A

Anticholinergic / Parasympatholytic

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16
Q

Atropine Dose?

A

0.01 mg/kg

17
Q

Atropine Onset?

A

1 minute

18
Q

Atropine Peak?

A

2 minute

19
Q

Atropine Duration?

A

1-4 hours

20
Q

Atropine MOA?

A

Muscarinic Receptor Antagonist - Competitively displaces acetylcholine at the Muscarinic Acetylcholine receptor, preventing parasympathetic stimulation.

21
Q

Atropine Side Effects?

A

Increase in HR R/T vagal inhibition of the SA and AV conduction

22
Q

Edrophonium Class?

A

Anticholinesterase

23
Q

Edrophonium Dose?

A

0.5-1 mg/kg MAX 40 mg

24
Q

Edrophonium Onset?

A

30 seconds to 1 minute

25
Q

Edrophonium Peak?

A

1 minute

26
Q

Edrophonium Duration?

A

45 minutes

27
Q

Edrophonium MOA?

A

Cholinesterase Inhibitor - Binds REVERSIBLY to the negative charge on Acetylcholinesterase preventing Acetylcholine breakdown.

28
Q

Edrophonium Side Effects?

A

Bronchoconstriction, Decrease in HR/BP/CO/IOP, increases secretions and nausea, NOT recommended for a deep block.

29
Q

Edrophonium Metabolism?

A

75% Renal and 25% Hepatic

30
Q

Scopalomine Class?

A

Anticholinergic

31
Q

Scopalomine Dose?

A

0.2-1 mg (usually IM)

32
Q

Scopalomine Onset?

A

5-10 Minutes

33
Q

Scopalomine Peak?

A

20-60 minutes

34
Q

Scopalomine Duration?

A

2 hours

35
Q

Scopalomine MOA?

A

Muscarinic Receptor Antagonist - Competitively displaces acetylcholine at the Muscarinic Acetylcholine receptor, preventing parasympathetic stimulation.

36
Q

Scopalomine Side Effects?

A

Bronchodilation, Increase in CO, decrease motion sickness nausea, decreases secretions, amnesia and sedation

37
Q

Scopalomine Metabolism?

A

Hepatic with Renal excreation

38
Q

Neostigmine Metabolism?

A

50% Hepatic and 50 % Renal

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