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Pharmaceutics II > Suppositories > Flashcards

Suppositories Flashcards

1
Q

Define suppositories

A
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2
Q

Suppositories are commonly used how

A

Rectaly and vaginaly and occasionally urethrally

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3
Q

What is the shape and weight of the suppositories

A
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4
Q

Once inserted what happens to the suppositories

A

Melts, softens or dissolves distributing its medicaments to the tissues of the region

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5
Q

How are suppositories used locally

A
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6
Q

How are suppositories used systemically

A
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7
Q

What are the advantages of suppositories

A
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8
Q

What are the types of factors affecting drug absorption from rectal suppositories

A

Physiological factors
Physicochemical factors of the drug and the base

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9
Q

What are the physiological factors

A

Colonic content
Circulation route
pH and lack of buffering capacity of the rectal fluid

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10
Q

Explain the colonic content factor

A
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11
Q

Explain the circulation route factor

A
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12
Q

Explain the pH and lack of buffering capacity of the rectal fluid

A
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13
Q

What are the physicochemical factors of the drug and base

A

Lipid-water solubility
Particle size
Nature of the base

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14
Q

Explain the lipid water solubility factor

A
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15
Q

Explain the particle size factor

A
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16
Q

Explain the nature of the base factor

A
17
Q

What are the two types of suppositories bases

A

Fatty or oleaginous bases
Water soluble bases

18
Q

Why are fatty bases the most frequent employed suppository base ?

A

Because cocoa butter is a member of this group of substances

19
Q

What are the other fatty material used in suppository bases

A

Hydrogenated fatty acids of vegetable oils, such as palm kernel oil and cottonseed oil

20
Q

The bases in many commercial products employ varied combinations of these types of materials to achieve what

A

Desired hardness under conditions of shipment and storage
Desired quality of submitting to the temperature of the body to release their medicaments

21
Q

Define cocoa butter

A

Fat obtained from the roasted seed of theobroma cacao

22
Q

What is cocoa butter like at room temperature

A

Yellowish-white solid having a faint, agreeable chocolate-like odor

23
Q

What is cocoa butter chemically

A

It is a triglyceride

24
Q

Why is cocoa butter ideal suppository

A
25
Q

What is the limitation of cocoa butter

A
26
Q

How to overcome the cocoa butter limitation

A
27
Q

What is main members of the water soluble base

A
28
Q

How are glycerinated gelatin suppositories prepared

A
29
Q

Glycerinated gelatin base is most frequently used for what

A

Vaginal suppositories, with which of the medicinal agent is usually desired prolonged local action

30
Q

What is the difference between release rate of glycerinated gelatin base and cocoa butter

A
31
Q

Explain the limitation of glycerinated gelatin base

A
32
Q

How to overcome the limitation of glycerinated gelatin base

A
33
Q

Define polyethylene glycols

A
34
Q

PEG suppositories melt or dissolve

A

Dissolve

35
Q

How do PEG suppositories have slow release

A
36
Q

How are suppositories prepared

A

By molding
By compression

37
Q

What is preparation by compression suitable for

A

Making suppositories that contain heat-labile medicinal substances or a great deal of substances that are insoluble in the base

38
Q

What is the disadvantage of compression

A

Pharmaceutics II (16 decks)

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